New Scottish drug promising in battle against Covid-19

The new antiviral drug, developed by Pneumagen, a spin-out company at the University of St Andrews, has had positive clinical test results for Covid-19.

Pneumagen Ltd, a company focused on the treatment of infectious diseases and the development of tumor therapy targeting human glycomes, announced today (April 28, 2020) that corona containing the causative SARS-CoV-2 infection. Announcing the Results of Three In Vitro Studies on the Prevention of Viral Infections Covid-19 using Neumifil ™ and other class-first polyvalent carbohydrate binding modules (mCBMs), produced using the unique GlycoTarge ™ platform.

Successful studies included both treatment of infections and blockade of new infections.

Pneumagen worked closely with the Porton Institute of Public Health England and the MRC Virus Research Center at the University of Glasgow to test the activity of mCBM against coronavirus using a plaque reduction assay.

At both Porton and Glasgow Universities, the Pneumagen mCBM was found to reduce the number of SARS-CoV-2 plaques in these assays when the mCBM was used to both prevent and treat infection.

Pneumagen now wants to launch clinical trials for the prevention and treatment of Covid-19.

Douglas Thomson, CEO of Pneumagen, said: “Today’s favorable results from in vitro studies of mCBM against coronaviruses indicate that glycan binding may prevent and treat infections.

“This further supports the value of our universal treatment of blocking access to lung cells by SARS-CoV-2 and other viruses that cause respiratory infections, and pan-viral Providing the potential for sex respiratory products, our goal is to quickly launch clinical trials for the prevention and treatment of Covid-19. “

Pneumagen’s study of Covid-19 is based on the company’s work with a variety of clinically relevant coronaviruses, which can cause a cold for which the plaque reduction assay also showed antiviral activity against mCBMs.

Pneumagen’s primary mCBM, Neumifil ™, has been developed for the universal treatment of respiratory infections (RTIs) such as influenza virus (IFV) and respiratory syncytial virus (RSV) and is now available. It is a coronavirus. A new mechanism of action of pneumifil, which covers glycan receptors in the patient’s respiratory tract and thereby prevents viral entry, provides clinicians with an opportunity to provide complete protection of the patient against circulating viral strains. , Could revolutionize the treatment of RTIs.

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