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Ultimovacs (ULTI) has published a publication in The Journal of Translational Medicine on the mechanistic basis of UV1 cancer vaccines to support Phase 2 study design for malignant mesothelioma.
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Ultimovacs ASA (“Ultimovacs”) (OSE ULTI), the clinical leader in immunostimulatory vaccines for cancer, today published a peer-reviewed article on the ongoing NIPU Phase II trial of our universal cancer vaccine UV1 in the malignant pleura. Mesothelioma (MPM) has been announced.Article Translational Medicine Journal We outline the rationale for the mechanism of the combination of UV1 and the two checkpoint inhibitors ipilimumab and nivolumab.
The dual use of ipilimumab and nivolumab was recently approved as the first-line therapy for MPM with few treatment options currently available.But as Hakensen et al As explained in the article, the response rates observed with checkpoint inhibitors are moderate and checked with MPM compared to the documented performance of checkpoint inhibitor combinations in other cancers. Point inhibitors alone may not be sufficient to provoke an immune response.
Early Phase I / II studies have shown that UV1 is safe on its own and, when used in combination with checkpoint inhibitors, induces a survival-related vaccine-specific immune response.
“The NIPU trial is important in understanding the potential synergies between checkpoint inhibitors and our universal cancer vaccine, UV1.” Said Ultimovacs Chief Medical Officer, Jens Bjørheim.. “Malignant pleural mesothelioma is a disease that is difficult to treat with checkpoint inhibitors that are effective against other types of cancer. In an article published today, how UV1 addresses that challenge. Explains if it helps. “
NIPU is a randomized, multicenter, open-label comparison of the efficacy and safety of nivolumab and ipilimumab in patients with inoperable malignant pleural mesothelioma after platinum-based first-line chemotherapy, with or without UV1. This is a proof-of-concept test (NCT04300244).
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