Oxford Biotherapeutics Named Best Technology Small Business of the Year

Oxford, UK and San Jose, CA, 22 July 2024 – Oxford BioTherapeutics (OBT), a clinical-stage oncology company with a pipeline of immuno-oncology and antibody drug conjugate (ADC) based therapies, has announced that it has been named Tech SME of the Year at the sixth annual Thames Valley Tech & Innovation Awards 2024. These awards celebrate the achievements of leading, diverse companies across the region.

OBT was selected as the recipient in recognition of its outstanding achievements in innovation, scientific excellence and commitment to improving patient outcomes, as well as its significant progress as an industry leader and key player in the ADC and T-cell derivation fields.

The Tech Small Business of the Year Award recognizes outstanding utilization of technology to advance company goals, improve communities, and/or empower customers. OBT received this award for its continued commitment and application of cutting-edge technology approaches, including the implementation of enhanced proprietary OGAP-Verify, mass spectrometry, and analytical biochemistry aimed at developing novel therapeutics to treat unmet needs in cancer. Notably, OBT's proprietary clinical assets are leveraged through the OGAP discovery platform, and collaborations leveraging this platform have resulted in a number of fruitful partnerships with industry leaders, further demonstrating the strength and versatility of target discovery technology.

Chief executive Dr Christian Rohrf said: “We are incredibly honoured to have been named Tech SME of the Year at the Thames Valley Tech & Innovation Awards. This award is testament to the hard work and dedication of all the teams at OBT who work hard to develop innovative therapies for cancer treatment. This year's win highlights the major technological advancements made for OGAP-Verify, our discovery database which aims to improve the success rate of cancer treatment. This accolade inspires us to continue in our mission of driving innovation and excellence for cancer patients.”

Last year, OBT won Technology Company of the Year and a special recognition award in the Thames Valley Small Business Growth 100 Awards, further cementing its reputation as a pioneer and leader in technology innovation in the region.

Oxford Biotherapeutics' Joseph Lewis, Lindsay Hudson and Somdatta Basu win Tech SME of the Year award at the Thames Valley Tech & Innovation Awards 2024

About Oxford Biotherapeutics

Oxford BioTherapeutics (OBT) is a clinical-stage oncology company with a pipeline of best-in-class immuno-oncology (IO) and antibody-drug conjugate (ADC) based therapies designed to meet unmet patient needs in cancer treatment, including bispecific, chimeric antigen receptor T cell (CAR-T), antibody-drug conjugate (ADC) and antibody-dependent cell-mediated cytotoxicity (ADCC) therapeutics.

OBT's lead clinical program, OBT076, began expanding U.S. clinical trials in patients with advanced or refractory solid tumors overexpressing CD205, including gastric, bladder, ovarian and lung cancer, in 2021. Tumor infiltration by immune suppressive cells correlates with adverse outcomes (reduced progression-free and overall survival), suggesting that this process contributes to the progression of several cancers.

OBT's proprietary OGAP-Verify target discovery platform is based on one of the largest proprietary cancer membrane proteome databases in the world, with data on over 5,000 cancer cell proteins providing unique and highly qualified tumor targets, three of which are programs in clinical development in the U.S. and Europe. OBT's IO discovery process has provided unique insights into the cancer-immune cell synapse and has identified several novel IO monoclonal and bispecific antibody candidates for cancer therapy.

OBT's pipeline and development capabilities are validated through multiple strategic partnerships, including cell therapy research collaborations with Boehringer Ingelheim, Immunogen and Kite Pharma, as well as other global leaders in antibody development, including Amgen, WuXi, Medarex (BMS), Alere (Abbott) and BioWa. OBT has a strong oncology-focused management team and board of directors with extensive experience in the development of IO and antibody-based therapeutics.

For more information about Oxford BioTherapeutics, please visit www.oxfordbiotherapeutics.com or follow us on LinkedIn.

Investor: Dr. Christian Rohlff, [email protected]

Media: MEDiSTRAVASylvie Berrebi, Sandi Greenwood, Erica HollingsworthE: [email protected]: +44 (0)203 928 6900

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