Health
The new protein-based Covid-19 vaccine does not require refrigeration: research
Scientists have developed a new protein-based vaccine candidate for Covid-19. They say it’s much easier to manufacture and doesn’t require refrigeration.
Researchers at Boston Children’s Hospital in the United States point out that currently available Covid vaccines require refrigeration and advanced production capacity, making it difficult to produce and distribute the vaccine widely, especially in developing countries. bottom.
They said the new vaccine design described in the PNAS journal would help fill the global vaccination gap and be applicable to vaccines against other diseases.New vaccine candidates elicited a strong immune response against Viruses that cause SARS-CoV-2 and Covid-19, And its mutant in mice, the researchers said.
The vaccine was successfully lyophilized and then reconstituted without loss of efficacy, adding that it remained stable and potent for at least 7 days at room temperature.
New Covid-19 vaccine It’s completely protein-based, according to researchers, so it’s easy to manufacture in many facilities. They said there are two components: an alpaca-derived antibody known as a Nanobody, and some of the viral spike proteins used to invade human cells.
“It is also possible to attach the entire peplomer or other parts of the virus,” said Novalia Pissha, lead author of the study.
“And you can change the vaccine for the SARS-CoV-2 mutant quickly and easily,” says Pissha.
In experiments with mice, Vaccine elicited strong humoral immunity against Stimulates SARS-CoV-2, a large amount of neutralizing antibody against peplomer fragments. They also stimulated helper T cells that elicit strong cell-mediated immunity and restore other immune defenses, the researchers said.
They said the vaccine is much more suitable for large-scale production because it is a protein rather than a messenger RNA like Pfizer / BioNTech or Modana vaccines.
“We don’t need the many great techniques and expertise needed to make an mRNA vaccine,” said Thibault Harmand, co-lead author of the study.
“Skilled workers are now a bottleneck in the production of Covid vaccines, but biopharmacy has extensive experience in producing protein-based therapies on a large scale,” Harmand explained.
Researchers said the new technology could enable vaccine production in many places around the world, close to where the vaccine is used. They have applied for patents on their technology and want biotechnology and pharmaceutical companies to bring their work to further trials and ultimately clinical trials.
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Sources 2/ https://www.indiatoday.in/science/story/coronavirus-protein-based-vaccine-sars-cov2-efficacy-1874309-2021-11-08 The mention sources can contact us to remove/changing this article |
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