Health
Merck’s Covid pills have been shown to be more promising in reducing the risk of hospitalization in recent studies.
The antiviral drug molnupiravir reduced the risk of hospitalization with Covid-19 by 65%. New research By Indian researchers who provided stronger results than previous studies on drug efficacy.
The study, led by researchers at the Chennai Antivirus and Clinical Research Site, divided 1,218 Indian adults who were infected with the coronavirus and experienced mild symptoms into groups of comparable size.
Only 1.5% of the group who took the pill required hospitalization, compared to 4.3% of the group who did not take the pill.
A last year’s study by Merck, who developed the pill with the help of Ridgeback Biotherapeutics, found that the drug reduced the risk of hospitalization by 30%.
In an interview on Saturday, Dr. Eliabber, senior vice president of the Merck Institute, said previous studies had some differences that made comparisons difficult.
Participants in the Merck study are at increased risk of developing complications after a Covid-19 diagnosis, Dr. Barr said. This study was also conducted worldwide and included patients with both mild and moderate infections. The Indian study did not target high-risk patients.
Still, “there are many similarities in research,” he said. “Both studies show a decrease in hospitalization. Both studies show a decrease in viral load, or viral load that can be detected in the nose, from pretreatment to posttreatment. , Both studies have significantly improved symptom resolution. ”
Antiviral drugs such as molnupiravir and Pfizer’s Paxrovid can infect more people than antibody treatments widely used in high-risk Covid-19 patients in the United States. Since the pandemic began Scientists wanted For convenient treatments prescribed by any doctor and received at local drug stores.
December Food and Drug Administration Molnupiravir approved for emergency use Depends on a particular adult at high risk. The drug is only available by prescription and should start within 5 days of symptoms, the FDA said, adding that it is not a substitute for vaccination.
Merck pills work by introducing errors into the viral genes to prevent replication. This raises concerns that it can cause reproductive disorders. Risk is a hypothesis, and Merck states that it is not supported by the study.
The FDA has stated that pregnant women should not generally take pills, but there may be exceptions. The agency stated that women of childbearing potential should use contraception while taking the pill and after at least 4 days. Authorities said that male partners of females who may become pregnant should use contraception while taking the pill and for at least three months.
Some scientists have also raised concerns that pills may not theoretically block viral replication and instead mutate the virus in ways that lead to the emergence of new variants.
Demand for Merckpill is weak in the United States due to reported low efficacy and safety concerns.
Until antivirals became available, patients wishing to receive Covid-19 had to go to the facility to receive infusions and injections, Dr. Barr said.
“It’s a pretty substantial barrier to being able to get treatment,” he said. “And that is a barrier that is likely to be disproportionately high in patients with the least access to health care.”
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Sources 2/ https://www.nytimes.com/2022/02/20/world/a-covid-pill-from-merck-showed-more-promise-in-reducing-the-risk-of-hospitalization-in-a-recent-study.html The mention sources can contact us to remove/changing this article |
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