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Iisc scientists say the Astama drug Montelukast can reduce Covid virus replication.Read here
Scientists at the Indian Institute of Science, Bangalore, have conducted a study showing that drugs used to treat Montercast-Astama may block the replication of Covid variants in infected individuals. Did.
This study was published in the journal eLife. “Montelukast sodium hydrate can be used as a lead molecule to design powerful inhibitors that help combat,” the study states. SARS-CoV-2 infectionMontelukast, which is used to reduce inflammation caused by symptoms such as asthma, hay fever, and hives, has been shown to be effective against Covid-19.
Medicine may be reduced SARS-CoV-2The study reveals that the virus that causes Covid-19 replicates in human immune cells.
Researchers at IISc have discovered that the drug binds strongly to one end (the “C-terminus”) of a SARS-CoV-2 protein called Nsp1. It is one of the first viral proteins released in human cells. This protein binds to the ribosome, the protein-producing mechanism in immune cells, and can stop the synthesis of important proteins required by the immune system, thereby weakening the immune system.
Tanweer Hussain, an assistant professor of molecular regeneration, development and genetics (MRDG), IISc and a senior author of the study, found the mutation rate of this protein, especially C-terminal regionIs very low compared to the rest of the viral protein, and Nsp1 is likely to remain almost unchanged in any variant of the virus that emerges, so drugs targeting this region will work for all such variants. It is expected that.
The latest research is against the backdrop of a surge in coronavirus cases around the world, including India. In India, Omicron continues to be the major variant of fresh cases.
Researchers have screened over 1,600 US Food and Drug Administration (FDA) approved drugs to find strong binding to Nsp1 using computational modeling. They then listed 12 finalists, including Montelukast and the anti-HIV drug saquinavir, to understand the stability of drug-binding protein molecules. The team then cultured human cells in a laboratory that specifically produces Nsp1 and treated them separately with montelukast and saquinavir.
They found that only Montelukast could save the inhibition of protein synthesis by Nsp1.
“There are two aspects. One is affinity and the other is stability. The anti-HIV drug (Saquinavir) showed good affinity, but not stability. , Montelukast has been found to bind strongly and stably to Nsp1 and allow host cells to resume normal protein synthesis. “
Researchers also tested the effects of the drug on live viruses at the Biosafety Level 3 (BSL-3) facility at the Infectious Diseases Research Center (CIDR). “Clinicians have tried to use this drug, but there are reports that Montelukast has reduced hospitalization for COVID-19 patients,” Hussein said, requiring a complete understanding of the exact mechanism by which it works. I added.
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