Health
Signs of an animal virus found in a person who received a pig’s heart
A 57-year-old Maryland man who had a heart transplant from a genetically modified pig and survived for two months showed signs of a virus that infects animals, according to the surgeon who performed the first surgery. rice field.
This disclosure supports one of the most pressing objections to animal-to-human transplantation. That is, the widespread use of modified animal organs may facilitate the introduction of new pathogens into the human population.
The presence of viral DNA in the patient may indicate an infection that contributed to the sudden exacerbation and death of March 8. Dr. Bartley Griffith, a transplant surgeon at the University of Maryland School of Medicine, said in a presentation to the American Society. Transplant.
Comments from Dr. Griffith First reported by MIT Technology Review..
Pigs have been genetically modified so that their organs do not promote rejection by the human immune system. The heart was donated to patient David Bennett Sr. by Revivicor, a regenerative medicine company based in Blacksburg, Virginia.
Company officials declined to comment on Thursday. University officials said the animals were screened for a virus called porcine cytomegalovirus. However, the test detects only active infections, not potential infections in which the virus may be quietly hiding in the pig’s body.
Bennett’s transplant was initially considered successful. He showed no signs of rejecting his organs, and his pig’s heart continued to function for over a month, passing an important milestone for transplant patients.
Testing showed that Bennett had pig CMV 20 days after the transplant, but at a low level that Dr. Griffith thought it could be a laboratory error. Forty-five days after surgery, Bennett became acutely ill, and subsequent tests showed a sharp rise in viral levels, Dr. Griffith said.
“So I started thinking that the virus, which appeared as a sparkle very early on the 20th day, began to grow over time. Maybe it was the actor who caused it all. Griffith and others. Told the transplant scientist.
Bennett’s health suddenly deteriorated 45 days after surgery, he said.
“On the 45th day, he looked really funky,” said Dr. Griffith. “Something happened. He looked sick. He lost his attention. He didn’t talk to us. He breathed hard and lay down on the bed, a little warm. . “
Heart transplants give hope to tens of thousands of patients in need of new kidneys, hearts, and lungs in the midst of a serious shortage of human organs donated, some breakthrough transplants in recent months. It was one.
However, the potential for unexpected consequences, especially the possibility of animal disease being introduced into the human population, can diminish enthusiasm for the use of transgenic organs.
Many scientists believe that the coronavirus pandemic is due to a virus that has transmitted to Chinese people from animals that have not yet been identified.
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Sources 2/ https://www.nytimes.com/2022/05/05/health/pig-heart-transplant-virus.html The mention sources can contact us to remove/changing this article |
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