Optimal CV health behavior may reduce the genetic risk of stroke

American Heart Association Simple7 of life Data from long-term analyzes show that even among people at high genetic risk, they protected people from stroke.

In an analysis of data on the risk of atherosclerosis in the community over a 28-year period, researchers found that black and white adults with a multigene risk score indicating an increased risk of stroke adhere to optimal CV health behavior. If so, I found that I would live about 6 years longer. Maintaining a healthy weight, not a healthy diet and smoking.

“We know that well-controlled and modifiable risk factors, especially the treatment of hypertension, can significantly reduce an individual’s risk of stroke.” Myriam Fornage, PhD, FAHA; A professor of molecular medicine and human genetics at the Institute of Molecular Medicine, University of Texas Health Sciences, said in a press release. “In our study, modifying other risk factors may reduce the lifetime risk of stroke, and good cardiovascular disease, regardless of genetics, whether the multigene risk score is high or low. It has been found that maintaining good health reduces lifelong risk of stroke. “

Fornage et al. Used 11,568 middle-aged adults (56% females, 23% blacks) using available genetic and Life’s Simple 7 data with no stroke at baseline and a median follow-up of 28 years. ) Data was analyzed. Researchers estimated the lifetime risk of stroke according to the level of genetic risk based on the validated stroke multigene risk score and the level of CV health based on AHA’s Life’s Simple 7 recommendations. For each ingredient — total cholesterol, BP, glucose, physical activity, diet, Smoking situation And BMI—Participants were categorized into “poor”, “intermediate”, and “ideal” groups.

The survey results are Journal of the American Heart Association.

At age 45, adults with high, medium, and low multigene risk scores have a residual lifetime risk of stroke of 23.2% (95% CI, 20.8-25.5), 13.8% (95% CI, 11.7-15.8), and 9.6. was. % (95% CI, 7.3-11.8), respectively. Beginning at age 45, inadequate, average and optimal Life’s Simple 7 participants remain at 17.6% (95% CI, 15.6 to 19.6) and 13.4% (95% CI, 11.8 to 15.1) long-term risk of stroke. I did. , And 9.8% (95% CI, 7.1-12.5). Researchers observed that 24.8%, the highest long-term risk of stroke, was observed in adults with high genetic risk and inadequate Life’s Simple 7 score (95% CI, 22-27.6).

In all categories of multigene risk scores, those with optimal Life’s Simple 7 scores had a 30% to 43% lower long-term risk of stroke compared to adults with inadequate Life’s Simple 7 scores. Patients with high multigene risk scores and inadequate Life’s Simple 7 had an average overall survival of 72.7 years and a minimum stroke-free survival of 66.7 years. However, patients with low multigene risk scores and optimal Life’s Simple 7 had the longest overall survival and averaged 76.7 and 74.1 years of stroke-free survival, respectively.

“This is equivalent to living for nearly six more years without a stroke,” the researchers write.

Researchers have found that maintaining optimal CV health is associated with the lowest estimated lifetime risk and the importance of modifiable risk factors in preventive efforts to reduce the risk of stroke. I write that it is emphasized. However, researchers warned that a “significant improvement” in the multigene risk score for stroke is still needed before achieving clinical utility, especially in the underrated population.

“But studies like us laid the foundation for motivating lifestyle and vascular health changes and realizing the potential for personalizing genetic risk information to prevent stroke.” The researchers write.