Health
COVID-19 and the Heart: Search for SARS CoV-2 Receptor Locations
Although about 20% of all COVID-19-related deaths are due to cardiac complications, the mechanisms by which these complications occur are controversial in the cardiology community.
One hypothesis focuses on infections of the heart itself, but it is unclear what cells are infected. To address this, Dr. Nathansacker, associate professor at the Masonic Institute of Medicine, collaborated with Broad Institute, University of Pennsylvania, and Bayer US on “ACE2 in Upregulation of Cardiomyopathy in Myocytes,” published in Circulation. It was.
COVID-19 (SARS-CoV-2) infects cells via a specific cell molecule called ACE2. To evaluate the molecular levels of various patient populations and their response to common hypertensive drugs (ACE inhibitors), the group applied state-of-the-art single nuclear sequencing technology to human heart samples. From these studies it can be concluded that the amount of viral receptors is increased in patients with pre-existing heart disease but only in the beating cells of the heart called cardiomyocytes.
In addition, they found that the effects of antihypertensive drugs, called ACE inhibitors, did not significantly affect ACE2 levels in such a way as to support changing clinical use of these drugs.
“This is just the early stage in understanding heart disease in people with COVID-19,” said Tucker, the first author of the manuscript. “There is much more to be done. For example, while we are already working to establish direct evidence of heart infection, we are also looking at receptor distribution from other populations and approaches. I would like to provide information as soon as possible.”
Although the study is only part of a very complex puzzle, this study provides a potential explanation as to why patients with existing heart disease are likely to suffer from severe cardiac symptoms due to COVID-19 infection. I am.
Importantly, it also provides data on the effects of antihypertensive drugs and additional human-derived data from the American Heart Association, American Heart Association and European Heart Association to facilitate continued use of ACE inhibitors. I support you.
The Masonic Medical Research Institute (MMRI) conducts clinical COVID-19 testing of the Mohawk Valley Health System (MVHS) and actively promotes COVID-19-related research in the laboratory, helping humanity to develop the latest corona It plays an active role in helping to fight the virus pandemic. Helping to understand the mechanisms by which COVID-19 worsens both cardiac and pulmonary function, identify potential novel therapeutic targets to treat patients, and potentially long-term potential for people who recover from this disease. Understand the consequences.
For more information on MMRI, visit mmri.edu.
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