Health
UCF researchers examine mechanisms of COVID-19 pathogenesis in patients with diabetes
Can COVID-19 infection have long-term health effects? people with diabetesincluding increasing the risk of heart disease?
Dinender Singla, Ph.D., a medical school researcher, believes that the genetic makeup of people with diabetes, or those predisposed to diabetes, predisposes them to post-COVID inflammatory conditions that affect the heart and brain.
We believe that COVID-19 may alter a person’s genetic makeup, driving the spread of the disease and exacerbating diabetes and related heart disease.”
Dr. Dinender Singla, AdventHealth Chair of Cardiovascular Sciences, School of Medicine
Dr. Singla has spent much of his research career researching heart failure, diabetes, and inflammation. In a recent article published in American Journal of Physiology–heart When circulatory physiology, He explored the mechanisms and possible effects of COVID-19 on high-risk diabetic patients, and the possibility that the virus could advance the disease, causing inflammation and heart failure.
“In our view, COVID-19 could have three major long-term effects on patients.
Dr. Singla pointed out. “One is the cognitive impairment that leads to Alzheimer’s disease; can exacerbate the complications of
Dr. Singla theorizes that some diabetics infected with COVID-19 may have different cellular compositions in their blood compared to diabetics who have not had COVID-19. The next step in his research is to analyze specific cellular differences in diabetic patients with and without COVID infection.
“Our goal is to see if there are differences in blood composition and cytokines (proteins that affect cell-to-cell communication) compared to non-COVID diabetic patients,” Dr. Singla said. If any differences are observed, we need to investigate what kinds of disease they might cause or enhance in those patients.”
With COVID-19 affecting more than 600 million people worldwide and vaccines making the virus less alarming today than it was two years ago, there are still many unanswered questions about the long-term health effects of COVID. There is a problem, says Dr. Singla.
“For example, if someone is genetically predisposed to heart disease or Alzheimer’s disease, if that person is affected by COVID-19, they will develop heart disease or Alzheimer’s disease sooner than they are susceptible. Is it?” said Dr. Singla. And what is the severity of the disease in people who are infected with COVID-19 and those who are not?”
Dr. Singla said he is now working to secure funding to investigate the unresolved issues left after the virus.
“Do you want to know if diabetes will be present in patients infected with COVID-19 10 or 20 years from now?” Dr. Singla said. “Do they develop a particular type of cardiomyopathy or diabetic muscle pain and get worse? We will be one step ahead in developing treatments and cures for the disease.”
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Journal reference:
Narrasinghur, California, and others. (2022) Mechanisms of COVID-19 pathogenesis in diabetes. American Journal of Physiology – Heart and Circulatory Physiology. doi.org/10.1152/ajpheart.00204.2022.
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