Six minutes of HIIT may help delay the onset of Alzheimer’s and Parkinson’s

so crossover trial, the research team examined 12 healthy, healthy participants aged 18 to 56 years. Half of the participants were female, all had her BMI less than 25, and all engaged in regular physical activity.

People with chronic illnesses and taking medication daily were excluded from the study.

All participants underwent four different research plans.

• 20 hour fast
• 90 minutes of low-intensity cycling calculated at 25% of the participant’s peak oxygen consumption
• Six minutes of high-intensity cycling calculated at 100% of the participant’s peak oxygen consumption
• Combining exercise and fasting

Blood samples were tested for BDNF, glucose, insulin, and Ketone body β-hydroxybutyrate along with the platelet count.

The research team found a 9-fold increase in ketone body availability after 20 hours of fasting, which was not associated with significant changes in BDNF levels.

In contrast, serum BDNF increased by up to 14% after 90 minutes of light cycling, regardless of whether participants fasted. rice field.

Six minutes of high-intensity cycling increased the amount of circulating BDNF up to 5-fold over longer sessions of low-intensity cycling.

This increase was associated with a six-fold increase in lactate levels regardless of participants’ fasting. No increase in lactate levels was evident with low-intensity exercise.

The researchers also found that exercise increased circulating platelet count by 20%, concluding that exercise had a greater impact on platelet count than fasting.

medical news today We spoke with the study’s lead author Travis Gibbonson the importance of exercise type in this study.

He explained:[…] Any type of exercise is perfectly fine as long as it is intense enough to produce some lactic acid. The intensity required to do it is related to each individual. “

He went on to say that while the study participants worked hard, they did not have the best work rate. I will do my best for [seconds]”

“[P]People have a pretty good sense of pacing and choose an intensity that they feel they can sustain for at least that period of time,” he noted.

“I love seeing data that encourages people to live actively outdoors. It’s becoming clearer and clearer that just getting up and going out and aging, rather than looking for it, is a much easier, more effective and fairer way to stay ‘healthy’,” Gibbons says. explained.

Dr. Ryan GrattGibbons, a personal trainer and brain health coach at the Pacific Neuroscience Institute at Providence St. John’s Health Center in Santa Monica, California, was not involved in the study.

“[M]Most people, with or without cognitive decline, may not have the optimal “exercise prescription” for brain health, and an opportunity exists to fill that gap in clinical practice.
— Dr. Ryan Gratt

“[…] This study, […] “This is of interest to further our understanding of how exercise variables such as intensity and duration, in combination with dietary behavior, influence factors of brain health such as BDNF expression,” said Dr. Glatt. MNT.

“The most interesting part of this study is the combination of fasting and exercise and the individual arms. It’s important because it’s a diet,” he continued.

“[I]It is appropriate to develop a lifestyle that prioritizes brain health before symptoms of neurodegeneration appear. “
— Travis Gibbons, study author

This study is limited by the small sample size and lack of a control group.

“[T]His study, due to its low statistical power and multimodal study design, raises more questions than answers,” commented Dr Glatt.

However, the authors argue that exercise is “an accessible, affordable, efficient and equitable intervention” that can be easily incorporated into daily life.

“Another question may be what the significance of BDNF expression is in the context of this study, as cognition and other aspects of brain function were not measured.[…]added Dr. Gratt.

He said future research will explore “how important those benefits are, what kinds of benefits exist (cognition, brain function, structure, or mood), and how long those benefits last.” emphasized the need to focus on

The next step in this work is to understand whether combining exercise and fasting alters neuroprotective effects.

“This will inform more strategies about the ideal ‘timing’ of exercise to achieve the best stimulation for brain-specific adaptations,” says Gibbons.

The team is also interested in understanding how exercise affects blood in the brain, and is working on research that will allow blood to be sampled from the brain during exercise.

“So far, we know that the blood in our brain is actually very different from the rest of the circulation,” Gibbons said.