Jacquerell Awarded Grant to Study Proteins Associated with ALS – Source

Amyotrophic lateral sclerosis (ALS), a relentless neurological disease, ultimately brings the whole body to a halt, but devastation begins at the molecular level. Over the years, researchers have linked ALS, also known as Lou Gehrig’s disease, to a handful of proteins that do not function properly due to genetic mutations. Over time, these distorted or “misfolded” proteins can aggregate in the brain and nervous system, impairing normal nerve function and slowly progressing to complete paralysis.

In theory, repairing and preserving these proteins could stop the disease. Meredith JackrellAssistant Professor of Chemistry in the Arts and Sciences at Washington University in St. Louis.

Neurological diseases may seem like an uncommon area of ​​research for chemists, but Jacquerel’s expertise in protein structure and function has positioned her to make real progress against ALS.

She has recently been working to advance studies of Matrin-3, a poorly understood protein that appears to play a pivotal role in some cases of ALS and frontotemporal dementia (FTD). Received a grant worth nearly $430,000 from the National Institutes of Health (NIH). A type of dementia caused by damage to neurons in the frontal and temporal lobes of the brain.

This grant will help Jackrel build on previous research that suggests possible progress in the fight against ALS.read more ampersand.

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