No increased risk of serious adverse events after COVID-19 vaccination

A cohort study of the entire Italian province population was found COVID-19 vaccination There was no increased risk of adverse events such as heart attack, stroke, cardiac arrest, myocarditis, pericarditis, or deep vein thrombosis.

From January 2021 to July 2022, studywas published in vaccinationevaluated the incidence of potentially vaccine-related serious adverse events by COVID-19 vaccination status. Investigators extracted data on all deaths and hospitalizations from severe cardiovascular disease, pulmonary embolism, and deep vein thrombosis from the National Health System.

This study is currently the only study in the world to monitor participants for more than 1 year, taking into account age, sex, and clinical risks for vaccinated and non-vaccinated patients.

During the 18-month follow-up period, 2097 people were hospitalized and 5743 died from serious adverse events that could be related to the vaccine. Notably, COVID-19 vaccinees (n = 259821) had fewer all-cause deaths, non-COVID-19 deaths, or serious illness potentially related to the vaccine compared to the unvaccinated cohort. It showed no increased risk of adverse events (n = 56494).

These results were consistent across gender, age, vaccine type, and COVID-19 transmission status. They showed no difference in the Cox model adjusted for age, sex, infection status, and various comorbidities.

“The results obtained clearly show that there is no increased risk of serious illness among vaccinated people,” said medical epidemiologist and professor of medical and surgical sciences at the University of Bologna. said one research coordinator, Lamberto Manzori.

The findings also confirmed that COVID-19 vaccinated individuals were more protected from the virus than unvaccinated individuals who recovered from infection. Even her one dose of her licensed COVID-19 vaccine significantly reduced her risk of death and serious vaccine-related adverse events.

Furthermore, those who received only one or two doses of the COVID-19 vaccine were more likely to have monitored diseases (severe cardiovascular disease, pulmonary embolism, deep vein thrombosis) was high.

“Although there have been isolated adverse cases, the safety profile of the vaccine used during the pandemic has been confirmed. It is now important to continue follow-up over a longer period of time,” Manzoli emphasized. .

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