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COVID-19 antibody may fall within a few months

 


July 15, 2020-Infection with SARS-CoV-2, a coronavirus that causes COVID-19, may reduce immunity within months, but New preprint paper. The study was released on medrxiv.org on Saturday and has not yet been peer reviewed.

According to British researchers at King’s College London and Guys and St. Thomas Hospitals in London, antibody responses began to decline about 20-30 days after symptoms began. They also found that antibodies were higher among people with more severe illnesses.

“This study has important implications for examining the persistence of SARS-CoV-2 reinfection protection and vaccine protection,” they wrote.

The research team sampled 65 COVID-19 patients from the onset of symptoms up to 94 days, and 31 healthcare workers who underwent antibody testing every 1-2 weeks from March to June. Tested They found that the “peak” antibody response occurred about 23 days after the onset of symptoms and declined by about 40 to 50 days after the onset of symptoms.

The authors write that some antibodies are 50 to 80 days old with symptoms, but additional research is needed to understand whether levels plateau or continue to decline.

Antibodies to other human coronaviruses also tend to decline over time, the researchers wrote and can last for months to years. The differences are probably related to the change in symptoms people experience and the severity of the disease, they write. For example, antibodies to the seasonal coronavirus associated with the cold are rapidly reduced and tend to lead to reinfection.

Researchers need to understand more about the antibody response to SARS-CoV-2, which has implications for clinical trials of vaccines. Even if the antibody levels drop, people may still have some protective immunity. Similarly, so-called “memory immune” cells, such as T cells and B cells, remember infections and reactivate the immune system, but can lead to milder infections.

“It seems that a certain amount of “COVID alert fatigue” has progressed over time since the SARS-CoV-2 virus emerged. “Dr. James Gill of Warwick Medical School said. In the statement Freed by the British Science Media Center on Monday. Gil was not involved in the study.

“A pre-print study found that there were antibodies to COVID, but it could warn people with mild symptoms, if any, to warn them,” Gil said. It was “Don’t be surprised if the protective effect is mild, or at least temporary.”

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