Health
Researchers at Boston University Discover How COVID Causes Deadly COVID-19 Pneumonia
Researchers at Boston University have discovered that the coronavirus can have fatal consequences by suppressing the ability of lung cells to get help from the immune system and instead activating inflammatory pathways. did.
“Infected lung cells infuse inflammatory proteins. In the infected person’s body, these proteins increase the level of inflammation in the lungs.
Kotton said studying the cells behind the lungs is often difficult due to their inaccessibility, but he and his team have been modeling human lung tissue grown from stem cells for years. I have been developing it.
“We already understood these techniques when the pandemic began,” said Cotton.
Organoids are not the same as living cells in the body, but they are very close to it.
Using this model, Kotton and his team use SARS-CoV-2 to block cells from activating one of the antiviral branches of the immune system early after the onset of infection. I found that.
These cells usually pump proteins in response to the threat of disease, but they are delayed for several days, giving the virus enough time to spread.
Other coronaviruses, such as SARS, also use this technique to evade the immune system, according to Cotton.
Researchers were also able to use the model to test some drug candidates, show promising results for COVID patients, and verify the effectiveness of Rendesibir, which has been granted an emergency license by the Food and Drug Administration. It was.
According to Cotton, drug screening is the most exciting and immediate application of the model, taking scientists one step closer to getting better coronavirus treatment.
“I think there’s another really important tool in the research community that was missing: access to deep human lung cells for drug screening and laboratory research,” said Cotton.
He said lung cells have already been shipped nationwide for use by other researchers.
“Understanding exactly how human lung cells react in the event of a disease-that new understanding empowers us all,” said Cotton.
The next big question that BU researchers and people around the world want to conquer is why the coronavirus is significantly more ill than others.
“When you have human cells to study, you can start understanding those really challenging questions,” Cotton said.
Kotton is also a physician at the Boston Medical Center and cares for patients with COVID-19 pneumonia.
“It’s very meaningful and inspiring, and during the enthusiastic pace there is always a moment of gratitude that we are all part of the community, people are very caring and help each other,” he said. Said.
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