Health

Personalized Cancer Treatment Improves Progressive Disease Outcomes-ScienceDaily

Patients treated for advanced cancer at the Moores Cancer Center at the University of California, San Diego survive without progression of disease when treated individually, according to researchers at the University of California, San Diego School of Medicine. Or they report that they are likely to experience it for a long time.

An interdisciplinary molecular tumor committee was established, led by Dr. Razel Kurzrock, MD, director of the Moores Cancer Center’s Personalized Cancer Treatment Center and senior author of the study, to provide molecular tumor composition for individual patients Use precision medicine strategy to advise doctors in the course of treatment.

“Patients who received the molecular tumor board recommended therapy were better suited to the genomic changes in the cancer and had improved outcomes,” Kurzrock said. “The 3-year survival rate for patients who received the most consistent or personalized cancer treatment was about 55, compared to 25% of patients who received treatment that did not match or had a low degree of agreement. %was.”

Of the 429 patients evaluated by the Molecular Oncology Commission, 62 percent matched at least one drug, the researchers reported in an online version on October 2, 2020. Nature Communications.. Twenty percent of patients were consistent with all recommended medications, including combination therapies.

The oncology committee plays an advisory role, and treating physicians do not use the committee’s recommended strategies in 38% of cases, instead with standards that do not match or are less consistent with the patient’s genetic alterations. Treatment approach was selected. These patients had low progression-free survival and overall survival.

Associate Professor Nobuaki Kato of the University of California, San Diego School of Medicine uses next-generation sequencing to identify new potential targets for cancer patients and improve outcomes, but this approach is widely used. There are challenges to doing. And the first author.

“One of the hurdles is that all cancer patients appear to have different molecular and genomic patterns, even though they have the same type of cancer,” specializes in rare gastrointestinal cancers. Kato, a medical oncologist at the Moore Cancer Center, said. “This can be difficult because we customize the treatment based on the patient’s unique genomic pattern, which makes it difficult to predict the response. In addition, this approach involves interdisciplinary expertise and Requires access to drugs and clinical trials that are not always available. Small practices. “

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material Provided by University of California, San Diego.. Original written by Yadira Galindo. Note: The content can be edited in style and length.

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