Health
Sofosbuvir, a hepatitis C drug combined with other safe antivirals for Covid-19, researchers claim
Results published in the journal Scientific Reports support the use of the USFDA-approved hepatitis C drug EPCLUSA (sofosbuvir / velpatasvir) in combination with other antiviral drugs in Covid-19 clinical trials.
SARS-CoV-2 exonuclease-based calibration readers maintain the accuracy of viral RNA genome replication and maintain pathogenicity.
Therefore, according to researchers, effective antiviral drugs that target SARS-CoV-2 polymerase must show a certain level of resistance to this calibration activity.
“Sofosbuvir-terminated RNA was found to be significantly more resistant to removal by exonucleases than remdesivir-terminated RNA, another drug used as a Covid-19 treatment,” said Columbia, USA. The university research author says.
The new research is based on previous research done by researchers.
In January last year, before Covid-19 reached a pandemic level, the team claimed that EPCLUSA could block SARS-CoV-2, the virus that causes Covid-19.
Their reasoning was based on an analysis of the molecular structure and activity of hepatitis C virus inhibitors and a comparison of hepatitis C virus and hepatitis C virus. Coronavirus Replication.
In one study, researchers showed that the active drug sofosbuvir triphosphate was incorporated by SARS-CoV and SARS-CoV-2 polymerases to stop the polymerase reaction.
Polymerases are enzymes that synthesize long chains of polymers or nucleic acids.
Since then, other researchers have demonstrated the ability of sofosbuvir to inhibit SARS-CoV-2 replication in lung and brain cells.
Covid-19 clinical trials using many hepatitis C drugs, such as EPCLUSA and the combination of sofosbuvir and daclatasvir (similar to velpatasvir), are currently underway in several countries.
The researchers noted that a recent preprint from the University of California, Berkeley showed that the combination of remdesivir and EPCLUSA increased the effectiveness of remdesivir in inhibiting the Covid-19 virus by a factor of 25.
“These results provide a molecular basis to support EPCLUSA’s work in combination with remdesivir for the Covid-19 clinical trial,” the team concluded.
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