Health
The accuracy of the rapid COVID-19 test may be lower than previously proposed
This study suggests that if 10% of people tested have been infected before, one in five positive test results will be inaccurate and will show false positive results. These conclusions differ from previous studies that suggest that the test does not give false positive results.
Findings suggest that this test can provide sufficient accuracy for population surveillance studies, but studies show that it is positive when these tests are used to provide evidence of protection from the virus. Laboratory confirmation of the results may be required.
The AbC-19 Rapid Test uses a drop of blood from a finger sting to see if someone may have been previously infected with SARS-CoV-2, without having to go to the laboratory 20 You will get results in minutes.
In June 2020, researchers tested blood samples of 2847 major workers in the UK (medical, fire, police staff, etc.) in the laboratory. Of these, 268 previously showed positive polymerase chain reaction (PCR) results, while the remaining 2579 had previously unknown infection status. In addition, pre-pandemic blood samples from 1995 were also tested as “known negatives.”
The research team estimated the specificity of the AbC-19 test to be 97.9%. This means that 2.1% of people who have never been infected with SARS-CoV-2 were falsely tested positive. In addition, they estimated the sensitivity of the AbC-19 test to be 92.5% based on cases confirmed by PCR, but studies show that it is significantly lower in people whose previous infection status is unknown prior to the antibody test ( 84.7%).
Studies show that people with positive PCR results tend to be more severe and are more likely to produce more antibodies, probably because higher antibody levels are more sensitive to testing.
In addition, trained laboratory staff noted that nearly 4% of AbC-19 tests often had a weak band of test results, disagreeing whether the results were positive or negative. According to the survey, the general public.
According to the author, this study has some limitations and may have overestimated performance because it evaluated the test in the laboratory rather than letting participants run the test themselves. In addition, the study included few people over the age of 65, suggesting that testing in the elderly at high risk for severe coronavirus disease in 2019 should be further evaluated.
Also, other lateral flow devices that detect antibodies to SARS-CoV-2 may not work well at low antibody concentrations. Although this study did not specifically investigate this, the authors of the study found that their study “overestimated the sensitivity of SARS-CoV-2 antibody testing in other studies whose sensitivity was estimated only from cases confirmed by PCR. It emphasizes the scope of. “
The authors of the study recommended further studies to clarify the relationship between circulating antibody levels and immunity to SARS-CoV-2, with a clear message that positive results from these assays do not provide evidence of immunity. Keep in mind that you need to tell the public.
reference
The accuracy of rapid covid tests may be lower than previously proposed. BMJ. https://www.bmj.com/company/newsroom/accuracy-of-rapid-covid-test-may-be-lower-than-previously-suggested/.. Released on November 11, 2020. Accessed on November 12, 2020.
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