Health
A new model has been developed that enables drug prediction for COVID-19
Researchers have developed a computational model of human lung cells. SARS-CoV-2, The virus behind COVID-19 The disease uses the host to survive and to enable drug prediction to treat the virus.
A study published in the journal Life Science Alliance uses a computer model of human lung cell metabolism to understand the stoichiometric amino acid and nucleic acid requirements of SARS-CoV-2.
Their model identifies host-based metabolic perturbations that inhibit SARS-CoV-2 reproduction and emphasizes responses in central metabolism, as well as amino acid and nucleotide biosynthetic pathways.
In fact, researchers have found that only a few of these metabolic perturbations can selectively inhibit viral replication.
“We have created a stoichiometric biomass function that causes Covid-19. SARS-CoV-2 virus And we incorporated it into a human lung cell genome-scale metabolic model, “said Orkun Soyer, a research author at the University of Warwick in the United Kingdom.
“Next, we predicted a reaction perturbation that could generally or selectively inhibit the reproduction of SARS-CoV-2 without inhibiting the maintenance of the host’s metabolism,” Soyer added.
The expected reactions are mainly classified into glycolysis and oxidative phosphorylation pathways, and their connections to amino acid biosynthetic pathways.
Taken together, these results highlight the potential for targeting host metabolism for inhibition of SARS-CoV-2 reproduction in human cells in general, especially in human lung cells.
“To investigate, we need to do more research. SARS-CoV-2 infected cells However, those metabolisms, the model developed here by researchers, can be used as a starting point for testing specific drug predictions, “says author Hadrian Delatre.
Indian coronavirus case In the last 24 hours, 41,810 new infections have occurred, reaching 93,92,919. 496 deaths have been recorded in the last 24 hours, reducing the number of active cases by 984. There are 4,53,956 active cases in the country. Over the past 24 hours, more than 42,000 people have recovered from fatal illnesses, with a total recovery of over Rs 880,000. The total death toll in the country is 1,36,696.
(With input from IANS)
Release date: November 29, 2020 18:46
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