Health

The 3D protein model shows why cats and cows are more likely to be infected with COVID-19 than chickens and pigs.

The coronavirus has already affected millions of people around the world, killing about 1.5 million COVID-19 patients. Although there have been numerous reports of virus-infected animals, new 3D protein models show that not all organisms become ill.

At the onset of the coronavirus pandemic, previous studies suggest that the health crisis began when the SARS-CoV-2 virus, which causes COVID-19, was transferred from the pangolins or bats to humans. Apart from these creatures, other animals such as cats and cows appear to be more susceptible to the virus than other animals such as chickens and pigs. The cause of such discrepancies is still unknown.

(Photo: Annie Spratt / Unsplash)
3D protein models show that not all animals are infected with COVID-19 – that’s why

3D protein models suggest why some animals are immune to COVID-19

by Phys.orgA new study by researchers at Stanford University in California claims that some creatures are more immune to COVID-19 and others are more susceptible to infection than other animals. João Rodrigues and his colleagues Announced their findings PLOS Computational Biology, an open access journal.

Researchers have developed a 3D structural model that shows how the receptor-binding domain of SARS-CoV-2 interacts with the human ACE2 receptor. This indicates that amino acids essential for human-viral interactions are present only in animal species susceptible to COVID-19 infection.

Rodriguez and his colleagues sought clues as to how infection begins: when SARS-CoV-2 protein spikes bind to ACE2 protein receptors on the surface of anima cells. Researchers used computer simulations to show the 3D structure of the protein and analyze how the spiked protein interacts with ACE2 receptors in a variety of animals.

(Photo: PLOS)
3D protein models suggest why some animals are immune to COVID-19

Rodriguez and his team have discovered that ACE2 in certain animals locks better against the virus. This makes them as vulnerable to COVID-19 infections as humans. These are just estimates, but the simulations conducted by the researchers were able to identify specific structural features specific to sensitive species of ACE2 receptors. In contrast, other species appear immune due to the lack of these functions at the ACE2 receptor, weakening the interaction of spike proteins.

Read again: COVID-19 Update: Evolution of a New Coronavirus Tracked in Bats; Studies Show That Some Animal Species Spread Undetectable and May Cause New Outbreaks

Future enhancements to 3D protein models

Rodrigues and his team continue to improve the tools used to compute this study, but their findings indicate that scientists and health officials trap the virus and interact with human ACE2 protein receptors. It may be useful in developing antiviral strategies using artificial “locks” to avoid.

(Photo: PLOS)
3D protein models suggest why some animals are immune to COVID-19

Rodriguez said the model could be strengthened to further monitor animals carrying viruses that could infect humans and “eventually prevent future outbreaks.” He also thanked preprints, open access data, and free academic software.

“I was wondering if a tiger could be infected with COVID-19, and in just a few weeks I got a 3D model of the protein structure that could explain why,” Rodriguez said. ..

Denmark has eliminated millions of COVID-19-infected minks

Back in November TechTimes reported About the Danish government’s plan to eliminate all 17 million minks in the country as mutated coronavirus strains were found in these pretty creatures.

At a news conference, Danish Prime Minister Mette Frederiksen announced a decision to prioritize responsibility over citizens and other countries to ensure that mink transmission to humans is prevented. Denmark has the largest mink fur industry in the world.

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