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That’s why some people develop life-threatening COVID-19 and others have no symptoms at all, Science News.
![That’s why some people develop life-threatening COVID-19 and others have no symptoms at all, Science News.](https://cdn.wionews.com/sites/default/files/styles/story_page/public/2022/01/28/236826-coronavirus.jpg,%20the%20researchers%20were%20able%20to%20create%20a%20precise%20map%20and%20identify%20genetic%20variations%20that%20contribute%20to%20the%20severity%20of%20COVID-19."%20typeof="foaf:Image"%20/> "That’s why some people develop life-threatening COVID-19 and others have no symptoms at all, Science News.")
Researchers in the United Kingdom have discovered 16 new genetic variants that may increase the severity of COVID-19 infection.
Some genes are associated with blood clotting, immune response, and intensity of inflammation.
“Our latest findings indicate specific molecular targets for critical COVID-19. These results show that some people develop life-threatening COVID-19 and others have no symptoms at all. “I’m explaining why,” said Professor Kenneth Bailey, a consultant in critical care medicine. University of Edinburgh.
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A single genetic variant that disrupts an important messenger molecule for immune system signaling, called interferon alpha-10, was sufficient to increase the patient’s risk of serious illness. Studies published in the journal Nature..
This shows the important role of genes in the immune system. It may suggest that treating patients with interferon, a protein released by immune cells to protect them from the virus, may be beneficial in the early stages of infection.
In addition, the study found that mutations in a gene that regulates the levels of key elements of blood clotting, known as factor VIII, are associated with a serious disease of COVID-19.
This may explain some of the abnormal coagulation seen in severe cases of COVID-19. According to researchers, factor VIII underlies the most common type of hemophilia.
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“It is no exaggeration to say that we have a better understanding of Covid’s mechanism than other syndromes treated with conventional intensive care, such as sepsis, influenza and other serious illnesses. COVID-19 It shows how to tackle us. These issues in the future. “
Researchers have sequenced the genomes of 7,491 patients from 224 intensive care units in the United Kingdom for the study.
The DNA of these people was compared to the DNA of another 48,400 who did not suffer from COVID-19 and 1,630 who suffered from mild Covid.
As a result of obtaining the entire genome sequence of each participant in the study, the researchers were able to create an accurate map and identify the genetic variation that contributes to the severity of COVID-19.
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The team discovered 16 genes in which the DNA of ICU patients differs from that of other groups.
A total of seven other genetic mutations associated with severe COVID-19 have also been confirmed in previous studies by the same team.
The findings could lead to new tests and treatments that help protect the general public from the virus, the team said.
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What Are The Main Benefits Of Comparing Car Insurance Quotes Online
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