Health
Long COVID symptoms may depend on dominant mutations
Italian researchers have discovered that the predominant circulating mutants may be involved in the symptoms experienced by people with long experience with COVID.
Of the more than 400 COVID-19 patients admitted, 76% have persistent dyspnea (37%), chronic fatigue (36%), insomnia (16%), visual impairment (13%), or post-discharge. Brain fog (13%) with a median follow-up of 53 days was reported by Dr. Michele Spinich of the University of Florence, Italy, and his colleagues.
Wild-type SARS-CoV-2 is circulating, the authors are noted in their poster and it is presented at European Conference on Clinical Microbiology and Infectious Diseases (ECCMID) In April in Lisbon, Portugal.
On the other hand, during the alpha wave, persistent anosmia and dysgeusia were less frequent.
Multivariate analysis showed that certain factors were associated with a greater risk of long COVID symptoms.
- Use of immunosuppressive drugs: OR 6.4, 95% CI 1.5-28.0
- Female Gender: or 1.8, 95% CI 1.1-2.9
- Increased oxygen support: or 1.4, 95% CI 1.1-1.8
Notably, patients with type 2 diabetes had a reduced risk of developing long-term COVID symptoms (OR 0.4, 95% CI 0.2-0.7).
“Many of the symptoms reported in this study have been measured, but this is the first time they have been associated with a different COVID-19 mutant,” Spincci said in a press release. “The long-term, widespread symptoms remind us that: The problem has not been resolved, And we need to do more to support and protect these patients in the long run. “
Spinicci et al. Retrospectively investigated data from electronic medical records of 428 patients admitted to the Caleggi University Hospital in Florence from June 2020 to June 2021. The median age of patients was 64 years, with 59% being male. The average length of stay was 10 days.
Common comorbidities included hypertension (43%), congenital heart disease (19%), and diabetes (19%). According to the WHO severity scale, 38% of patients had moderate symptoms, 23% had severe symptoms, and 19% had severe symptoms. More than half of the patients needed low flow oxygen support, 23% needed non-invasive ventilation, and 9% did not need oxygen support. Almost 70% were given steroids, 22% were given remdesivir (Veklury), and 21% were given hydroxychloroquine.
During follow-up, patients were seen at an outpatient clinic and completed a questionnaire assessing their persistent symptoms.
The authors acknowledged some restrictions on the study, including designs for which the cause and effect could not be proven. Also, it was not possible to determine which variant caused the infection.
“Future research needs to focus on the potential impact of the variant of concern. Vaccination status About the ongoing symptoms. “
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Disclosure
Spinicci and co-authors reported no conflict of interest.
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