Health
Dicavirus, scientists warn that one mutation has left the global outbreak
New research has discovered that the Zika virus may be a single mutation away from the explosion to a global outbreak. The infectious virus that caused the global health emergency in 2016 is a new contagious variant that can cause catastrophic birth defects that affected many infants during the previous outbreak. You need to change the genetic code once to create.
The results of a study conducted in mice by researchers at the Lahora Institute of Immunology, California, Cell report journal.
Emergent viruses, especially those that pose a health risk to humans, are constantly being monitored and tested to identify potential threats and treatments. Experts dealing with coronavirus suggest theoretical changes that may alter the transmissibility of the viral genome. Other viruses such as Zika virus are no exception.
Zika fever spreads primarily through mosquitoes and presents with relatively mild symptoms. However, pregnant women infected with the virus pass it on to the fetus, causing microcephaly, the baby’s head becoming smaller, and the brain not developing. The Zika epidemic, which began in Brazil and affected the Americas in 2015 and 2016, has caused more than 3,500 infant microcephaly. The World Health Organization said it represents a serious and long-term problem.
New studies have identified the evolutionary potential of deer that may make it possible to increase infectivity, even in countries unaffected by previous outbreaks. Using a mouse model and mosquitoes, researchers have discovered small genetic mutations that simulate the transfer of the virus between the vector and the human host, enhancing the infectious properties of the virus. It suggests that it creates a variant that can circumvent the immunity provided by past infections with dengue or similar pathogens, allowing the mutation to return the deer to a previously affected country. Did.
In an interview with BBC newsThe study’s lead author, Professor Sujan Shrestha, said the identified Zika virus has evolved to the extent that cross-defense immunity brought about by previous dengue infections is no longer effective in mice.
Researchers added that if this variant becomes widespread, the same problem needs to be dealt with in practice.
India recently reported more than 120 outbreaks in November in the fight against the outbreak of its own Zika fever with Kanpur in Uttar Pradesh.
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