Covid-hit Brit tested positive in 505 days of record breaking

Patients were continuously positive for Covid-19 testing for 505 days prior to death. This is the longest time it is known that someone has been infected with the virus.

British patients who tested positive continuously for almost two years are expected to have suffered from mutations that cause persistent infections before they died. The longest known PCR-confirmed case before is believed to be 335 days.

Researchers also discovered one of the first “occults” COVID Infection. Latent infection means that the patient is believed to have cleared the virus and the test to prove it was negative, but the infection was ongoing and was not detected.

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Scientists have studied nine individuals in London whose immune system has been weakened due to medical treatment of organ transplants, HIV, cancer, or other illnesses.

They were all tested positive for the virus for at least 8 weeks. The infection lasted an average of 73 days, but two patients had a persistent infection for over a year.

Five of the nine patients survived. One patient who had received Covid-19 for 505 days died, but another patient has been infected for 412 days.

They are being treated with monoclonal antibodies to try to get rid of their infection. If the test continues to be positive, it may pass the 505-day record.

Dr. Luke Bragdon Snell of Guy’s and St Thomas’NHS Foundation Trust said: Some of these variants are more easily transmitted among people, cause more serious illnesses, or reduce the effectiveness of vaccines.

“One theory is that these viral variants evolve in individuals whose immune system is weakened by diseases that may be persistently infected with SARS-CoV-2 and medical treatments such as chemotherapy. These people with persistent infections. “

“This provides evidence that the mutations found in the variant of concern occur in immunocompromised patients, thus supporting the idea that new variants of the virus may occur in immunocompromised patients. However, it is important to note that none of the individuals who participated in our study developed a new mutant of concern, which is a widespread variant of concern.

“Furthermore, this study shows that mutations can occur in people with immunodeficiency, but it remains unclear whether mutations of previous concern such as alpha, delta, and omicron have occurred in this way. “

Co-author Dr. Gaia Nevia said: This can also prevent the emergence of variants. An occult infection is a person who, for example, is thought to have cleared the virus with a negative test, but later found to have an advanced infection.

“This is explained by other viruses, such as the virus that causes Ebola and hepatitis B, unlike the long Covid, which is generally thought to be cleared from the body but has persistent symptoms. It was a therapy and had a positive Covid test before recovery.

“Then, several months later, before the onset of Covid symptoms again, it was negative several times. The PCR test was positive, and the genomic sequencing of the virus at this point was that the infection was caused by an alpha mutant. It suggests that the virus has been present in the body since the first infection, but was not detected. “

The study was presented at the European Conference on Clinical Microbiology and Infectious Diseases (ECCMID) in Lisbon, Portugal.

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