Media Advisory

Thursday, July 14, 2022

what

Researchers and their collaborators at the National Cancer Institute, which is part of the National Institutes of Health, were founded by European and African ancestors hospitalized with COVID-19. OAS1 Than mildly ill patients who are not hospitalized. People with this combination of genetic variation also remain positive for SARS-CoV-2 infection for longer. However, interferon treatment may reduce the severity of COVID-19 in people with these genetic factors. Interferon is a type of protein that can help the body’s immune system fight other diseases such as infections and cancer.

The study will be displayed on July 14th Nature Genetics.

These findings suggest that genetic factors such as genetic mutations that affect the OAS antiviral protein that facilitates the detection and degradation of SARS-CoV-2 virus may affect the risk of SARS-CoV-2 infection. It is based on previous studies that suggested that there was.

NCI researchers and their collaborators have found that treating cells with interferon reduces the viral load of SARS-CoV-2. Researchers also analyzed data from clinical trials in which unhospitalized COVID-19 patients were treated with recombinant interferon pegIFN-λ1 and found that treatment improved viral clearance in all patients. ..Who has OAS1 The risk variant has benefited the most.The results show that interferon treatment may improve the outcome of COVID-19, especially in certain patients. OAS1 Genetic variation that impairs the ability to get rid of the infection.

Who

Ludmila Prokunina-Olsson, Ph.D. and Oscar Florez-Vargas, Ph.D., Department of Cancer Epidemiology and Genetics, National Cancer Institute

reference

“Gene regulation OAS1 Nonsense mutation-dependent disruption underlies the association with COVID-19 hospitalization in patients of European and African ancestry. ” Nature Genetics..

About the National Cancer Institute (NCI): NCI is leading the National Cancer Program and NIH’s efforts to dramatically reduce cancer prevalence and improve the lives of people with cancer. NCI supports a wide range of cancer research and extratumor training through grants and contracts. NCI’s In-Wall Research Program includes innovative, interdisciplinary foundations, translations, and clinical research on cancer causes, preventative measures, risk prediction, early detection, and treatment, including research at the NIH Clinical Center, the world’s largest research hospital. , I am doing epidemiological research. For more information on NCI’s in-wall study, Cancer Research Center And that Cancer Epidemiology and Genetics.. For more information on cancer, please visit the NCI website. cancer.gov Alternatively, call the NCI Contact Center (1-800-4-CANCER (1-800-422-6237)).

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