Health
Antibiotics found in potato disease block fungal infections
Antibiotic resistance is a concern for both human and plant health. The more we use existing antibiotics in clinical practice and agriculture, the more develop antibiotic resistanceWithout new antibiotic compounds, both humans and plants will struggle to treat diseases that were once controlled.
exciting new research From Europe, details the discovery of a new antifungal antibiotic called solanimycin that is hidden inside the bacteria that causes disease in potatoes.
most therapeutic antibiotics actually derived from soil microbesthus, this discovery broadens the search for new compounds to plant-based microbes.
Dr Rita Monson, a microbiologist at the University of Cambridge and one of the study’s authors, said:
the bacteria themselves known as Dikeya Solanianother antibiotic called Ausidin A, originally isolated from bacteria and used as an effective fungicide against many plant diseases, has been known for more than 15 years.
This, along with sequencing of the bacterial genome, has led researchers to realize that other antibiotic compounds may be lurking in the background. The gene responsible for the production of osidin A is switched off, and when the bacteria are in an acidic background such as inside a potato, the gene responsible for the production of solanimycin is switched on.
“This is an antifungal that we believe works by killing the fungus’ competitors, and the bacteria benefit a lot from this,” Monson said. Do not turn on the power unless you are
Antibiotic resistance: an arms race that lasts millions of years
Solanimycin has been demonstrated to act against fungal diseases of both plants and Candida albicansoccurs naturally in the body, but can get out of control and cause dangerous infections.
Monson and colleagues wanted to understand more about solanimycin and how it works, so they worked with chemists to explore its molecular structure in detail.From there, they proceeded to test the compound in plant and animal models. I hope
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