Health
Genetic map of cells that cause endometriosis may improve treatment
Mapping the cells involved in endometriosis could improve our understanding of how genetics influence the risk of the condition and open the door to new drug targets
health
January 9, 2023
Cells involved in endometriosis have been genetically mapped as part of a small study that may lead to new treatments for this condition.
According to the World Health Organization, endometriosis affects approximately 1 in 10 women worldwide. It occurs when tissue that resembles the lining of the uterus grows in other parts of the body, such as the ovaries, fallopian tubes, and the lining of the pelvis. Symptoms include: pain the difficulty of becoming pregnantThere is no cure and there are existing treatments aimed at relieving symptoms.
The cause of endometriosis is unknown, but it often occurs in families.to better understand genetically The pathways involved in this condition could lead to the development of new treatments, they said. Kate Lawrenson at Cedars-Sinai Medical Center in Los Angeles, California.
To look for a genetic link, Lawrenson and her colleagues collected more than 400,000 cells from pelvic tissue from 21 women aged 21 to 62. Her remaining four women were undiagnosed with endometriosis and served as a control group.
The researchers sequenced these different cells and created a map of gene expression in cells affected by endometriosis.
Maps has led teams to identify genetic mutations whose effects on cells could one day be drug targets for endometriosis. This mutation appears to affect lymphatic vessels surrounding endometriotic lesions. Previous research suggests that endometriotic tissue may spread around into the body via the lymphatic system.
“This study presents a potential route and target for investigation of endometriosis.” Lucy Whitaker at the University of Edinburgh, England. But given the small sample size of her study, she says the endometriosis map is inconclusive.
Nonetheless, she says, the study will allow us to better understand the cellular characteristics of endometriosis, which may lead to new therapeutic targets.
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