Liver Growing in Pig Lymph Nodes May Help Treat Liver Diseases: Research

Ah liver Raised in Lymph node The treatment of pigs is Liver diseaseaccording to, New research.. University researchers Pittsburgh The medical school has shown that pigs with liver damage can use their own hepatocytes, a type of hepatocyte that acts as a natural regenerator, to grow new organs in the lymph nodes.

Coffee May Protect Your Liver, New Research Suggests

“It’s all about places, places, places,” says senior research author Eric Lagas, Pharm.D. , Ph.D. Said in a press release. “When hepatocytes reach the right places and need liver function, they form ectopic livers in the lymph nodes,” says Lagasse, associate professor of pathology at the University of Pittsburgh. news release.

Researchers have shown that liver-damaged pigs can use their own hepatocytes, the hepatocytes that function as natural regenerators, to grow new organs in the lymph nodes.

This is good news for patients with primary cholangiocholangitis (PBC) like Meredith Stone. PBC is an autoimmune disease that attacks the bile ducts of the liver and can create scars and cause liver failure.

“The idea that a liver transplant is needed has always been deep in my mind,” Stone said in an interview with Fox News. “I try to stay healthy, but it’s scary. It’s not one of the “popular liver disorders”, so it doesn’t get much attention in the study. Unfortunately, I can only pray for miraculous cures every day. “

Patients at high risk of coronavir should be aware of this common liver condition. Warn the doctor

Stone said the new study gave her hope and said, “Maybe this could spark the way to successful treatment and treatment for PBC and other liver diseases.”

According to a university news release, researchers have recreated liver disease in a group of pigs by circumventing the blood supply from the liver and at the same time excising a portion of a healthy liver. They reportedly extracted hepatocytes from healthy tissue and injected them into the abdominal lymph nodes of the same pig.

Studies have shown that all six pigs recover hepatic function, with lymph nodes showing hepatocyte proliferation and the naturally formed bile duct network and vasculature between transplanted hepatocytes. It was done.

“The cells of the liver usually replenish themselves, but they need a healthy and growing environment to regenerate. In end-stage liver disease, the liver is bound to scar tissue and toxic to the cells. It won’t happen again,” the researchers explained in a press release.

The new accessory liver has grown in size depending on how damaged the original liver was, researchers say in their report. The authors of the study announced that it had shown that the pig body was able to maintain equilibrium rather than producing abnormal, chaotic growth, which resembles cancer.

New findings support previous results Investigation Researchers at Lagasse and Mayo Clinic have shown that damaged liver was repaired by healthy liver tissue grown in lymph nodes of pigs with a genetic liver defect. According to a college news release, the study showed that healthy cells spontaneously migrated to replace diseased hepatocytes and cure liver disease in animals.

The team of researchers hopes the results will lead to the treatment of various liver diseases, and said human clinical trials will follow.

“Generating auxiliary liver tissue using lymphocytes as hepatocyte engraftment sites is a potential therapeutic approach to compensate for reduced liver function in the treatment of liver disease.”

Dr. Douglas Dietrich, Professor of Medicine and Liver Diseases at Mount Douglas The Sinai Hospital in New York City was not part of the study, but told Fox News: “Using the lymph nodes to grow the liver is an interesting idea to take advantage of the liver’s great regenerative capacity to grow and repair. Success in pigs is very promising, but of course the next step is To see if it works in humans.

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