Health
Fish oil can help with cardiovascular disease
Meanwhile, the STRENGTH trial used a treatment that included both EPA and the omega-3 fatty acid docosahexaenoic acid (DHA). Used for hypercholesterolemia and heart disease..
The STRENGTH trial has enrolled more than 13,000 patients in 22 countries since 2014. It was discontinued in January 2020 when it was discovered that carboxylic acids, including amino acids and fatty acids, had no effect. According to a press release, corn oil placebo was used because of its neutral effect in this study. He said mineral oil would create “negative controls.”
“Unless another study with a neutral placebo, such as corn oil, can clearly demonstrate the cardiovascular benefits of omega-3 fatty acid drugs, questions about the benefits and risks of fish oil remain unanswered. We believe, “he said.
Unlike the mineral oil used in the REDUCE-IT trial, corn oil did not raise low-density lipoprotein cholesterol (LDL, which is considered “bad” cholesterol) or two important biomarkers, Linkov said. .. He said it suggests that “it was a really neutral comparator.”
Similar results were obtained on the ONEMI trail.
“The fact that there were no signs of the effects of omega-3 fatty acids in this group, along with the results of other recent neutral trials, suggests that omega-3 supplements are ineffective in cardiovascular prevention,” ONEMI said. The exam lead states. Investigator. Dr. A. Kalstad, Clinical Research Center, Oslo University Hospital, Oslo, Norway.
Discussing the REDUCE-IT trail and STRENGTH exam, Alberico Catapano, Ph.D. Said that it is not clear whether the effects of mineral oil or placebo fully explain the difference between the two studies.
“Given the current state of uncertain knowledge, neither patients nor physicians can be confident that omega-3 fatty acids have health benefits, but in 2019 the global market for omega-3 fatty acids will be $ 4.1 billion. Is expected to reach and double by 2025, “writes Deputy Editor-in-Chief Dr. Gregory Calfman.
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