Health
New studies suggest that damage to axons can stop neuronal growth
Axon damage can cause severe neurodegenerative conditions, according to a study conducted by a team of researchers at the University of California, San Diego. In addition, we have added suggestions on how it can be protected to promote neuronal growth. The long, thin protrusions perform electrical impulses from one nerve cell to another, enabling cell communication.
A paper published in the bulletin of the United States Academy of Sciences (PNAS) We have found that axonal damage often causes several neurodegenerative problems such as glaucoma and Alzheimer’s disease.
In addition, it was discovered that such damage can lead to neurological dysfunction and cell death. Researchers know that inhibition of an enzyme known as dual leucine zipper kinase (DLK) appears to provide strong neuronal protection in a wide range of neurodegenerative disease models and axonal regeneration. So far, no effective method has been established for modifying genes to promote regeneration and enhance long-term survival of neurons.
A joint team of researchers from the University of California, San Diego School of Medicine and the University of California, San Diego Health, Shiley Eye Institute has pointed out another family of enzymes known as germ cell kinase 4 kinases (GCK-IV kinases). The delay of the same is strong neuroprotection, allowing axonal regeneration and forming an excellent therapeutic procedure for treating some neurodegenerative diseases.
Derek Welsbie, MD, PhD, an associate professor of ophthalmology at the Viterbi Family Department of Ophthalmology at the Shiley Eye Institute, and senior authors Derek Welsbie, MD, and PhD, together with him and his team, a series of genes that allow optic nerve cells to pull when suppressed. Play through confirmed that you have resolved the existence. Researchers created retinal ganglion cells (RGCs) from human stem cells and then performed a series of screenings. The type of neuron found near the inner region of the retina of the eye is RGC. They collect visual data from photoreceptors and together help convey information to the brain.
A well-studied group of chemicals was part of the initial screening, which included tests to assess the ability of RGC to increase survival. The second, on the other hand, was to measure the ability to promote regeneration.
Welsby and colleagues conducted a study based on RGC when they were investigating optic neuropathy such as glaucoma. Glaucoma is a neurodegenerative disease identified by continuous loss of RGC and its axons, in addition to intraocular pressure, causing structural, measurable, functional harm to the optic nerve, as well as visual impairment and blindness. I will.
According to the US Centers for Disease Control and Prevention, it is estimated that 3 million Americans have been diagnosed with glaucoma. Glaucoma is the second leading cause of blindness. Welsby said the study recommended strong therapeutic potential, but warned that it was not yet confirmed whether the findings extended to other neuron types.
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