Health
Fat droplets help protect kidney cells from damage: research
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Has been updated: May 18, 2021 08:36 IS
London [UK], May 18 (ANI): Researchers at the Francis Crick Institute have discovered how microstructures called fat droplets can help prevent the cause of a high-fat diet. kidney damage. Fruit fly research published in PLoS Biology opens up new ones the study Road to better development processingChronic kidney disease.
Eating fatty foods can cause inflammation and metabolic stress kidneys, leading to chronic illness, in severe cases dialysis or transplantation is required.And with obesity increasing worldwide, it’s becoming more and more of a problem-about 10 percent of the UK people live chronically. kidney disease.
Click scientists have been ResearchAppearance of internal fat droplets, a common feature of the disease kidney cellTo solve the long-standing mystery of whether this protects or harms kidney function.
The team, in collaboration with Crick’s electron microscopy experts, uses advanced genetic techniques available in fruit flies (Drosophila) to help fat droplets protect the kidney system from damage from excess dietary fat. Shown.
When a high-fat diet is given, fat droplets accumulate in the kidney cells. This is equivalent to a fly. Human kidney cell They are called podocytes. Here, the droplets act as a “safe haven” to store excess fat away from the rest of the cells.
An enzyme called ATGL is located on the surface of fat droplets and helps to dispose of stored fat in a safe way. ATGL does this by supplying fat in a digestible form to nearby mitochondria, where it can break down fat into less toxic molecules.
Lipid When scientists use genetic methods to prevent their formation, droplets are essential to the protective process, as the fat that remains free in the kidney cells causes substantial damage and damage. kidney function.
Alex Gould, Head of Physiology and Metabolism Institute for Crick and Reed the studyEr Research “Fat droplets have long been known to appear in a variety of illnesses, from diabetes to brain tumors. It’s much less clear whether they are improving or exacerbating the situation.”
“Fat drops kidneyCounterattack against fat overload. These attractive structures have proven to be more than small balls of fat.And we now have those protective roles kidney It also applies to other illness situations. “
Scientists have also found that increasing the expression of the fruit fly’s ATGL enzyme can repair most of the damage caused by a high-fat diet and restore normal functioning. kidney cell..
Drosophila is a useful model for understanding the biology of kidney Illness Human■ Because there are important similarities in the renal system of both species, including the presence of the ATGL enzyme.
Ola Lubojemska, who performed much of this work at Crick’s Institute of Physiology and Metabolism, explains: “These findings are in their infancy, but open up new clinical directions. the study Chronically kidney disease. “
Ora added, “It may be possible to develop drugs that enhance the ATGL enzyme in patients with kidney disease, which could more efficiently detoxify excess dietary fat. kidney cell, So improvement kidney function. “(ANI)
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