Health
Studies find that statins can more than double the risk of dementia for some users-World News
Approximately 8 million British adults take statins daily, but a new study shows that patients with mild cognitive impairment more than double the risk of developing dementia when taking lipophilic statins. Is shown
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According to a new study, statins can more than double the risk of dementia in some users.
Fat cholesterol-reducing tablets are one of the most commonly prescribed medications in the UK and are taken daily by about 8 million adults to reduce the risk of heart attack and stroke.
In 2018 alone, more than 71 million prescriptions were dispensed.
However, a new study shows that patients with mild cognitive impairment taking lipophilic statins are more than twice as likely to develop dementia as those who are not taking statins. ..
Positron emission tomography (PET) scans of statin users revealed a “very significant” reduction in metabolism in the areas of the brain that were initially affected by Alzheimer’s disease.
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Patients with mild cognitive impairment or normal cognition who used lipophilic statins were found to be at least twice as likely to develop dementia as those who did not use statins.
Over time, PET imaging of lipophilic statin users shows a “substantial reduction in metabolism” in the posterior cingulate cortex, a region of the brain known to be most significantly reduced in the early stages of Alzheimer’s disease. Was also shown.
Statins help lower the level of low-density lipoprotein (LDL) cholesterol (known as “bad cholesterol”) in the blood and reduce the production of cholesterol in the liver.
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Different types of statins are available based on the patient’s health needs.
It includes hydrophilic statins that focus on the liver and lipophilic statins that are distributed throughout the body’s tissues.
The researchers divided the study participants into three groups: baseline cognitive status, baseline cholesterol levels, and the type of statin used.
Participants underwent PET imaging to identify areas of reduced brain metabolism within each statin group. Eight years of clinical data were also analyzed.
Patients with mild cognitive impairment or normal cognition who used lipophilic statins were found to be at least twice as likely to develop dementia as those who did not use statins.
Dr. Prasanna Padmanabham of the University of California, Los Angeles said: “By characterizing the metabolic effects associated with the use of statins, it offers new applications for PET and is one of the most common pains of drugs and the aging brain.”
He added:
Determining which statin is best for cognitive maintenance and the ability to function independently. “
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