Health
Antibiotics-Pipeline-Coronavirus-Healthcare-Incentives-Axios
This pandemic can be caused by a virus, but desperate measures to save the patient often include overprescription of antibiotics, Antibiotic resistance.
Important reasons: Antimicrobial Resistance (AMR) requires clinicians to look for other drugs to treat patients, Antibiotic pipeline Is in Tragic channel. The COVID-19 pandemic shows how few options are available, exposing the need for investment to prepare for the emergence of antibiotic-resistant infections, industry experts tell Axios.
Driving news: The Government Accountability Department last week To report When 8 recommendations For the federal government on how to better identify and address issues.
- The possibility of the need of the Ministry of Health and Welfare was included “ As such incentives develop, more and more drug companies may withdraw from the antibiotic development sector and the pipeline of new treatments may continue to decline, ” demanding authority and budget, and post-marketing. Create and implement your financial incentives. (HHS Did not agree Including recommendations for post-market incentives).
- “Because evolution affects bacteria and viruses, these are areas where we need or need to be prepared for drugs that we don’t really need yet,” said Boston University Health. Says Co-Director Kevin Oughterson. Executive Director of Law Program and Non-Profit Organization CARB-X.
- Cases: If a company produced the COVID-19 vaccine in 2018, it had zero value at that time, Outterson said. But for now, “What is it worth? It’s almost immeasurable, how valuable it is now. It’s worth trillions of dollars today.”
By numbers: Outterson says 15 antibiotics have been approved by the FDA over the past decade, and almost all have been brought to market by SMEs.
- “But in the last 13 months, one-third of them went bankrupt, [have been] It was sold in a deal where the value of the drug was essentially zero — and that, as I tell you, is a huge proportion of catastrophes, ”says Outterson.
- Only small businesses were willing to take risks Big Pharma Doesn’t See IncentivesHe said, and now “there are few people who want to risk their money.”
- One of the problems is that as new antibiotics are developed, their use is limited to protect their effectiveness. In addition, some insurance companies are rushing to cover new, often more expensive antibiotics.
- In 2019, Achaogen and Melinta Therapeutics declared bankruptcy due to slow sales of newly approved antibiotics, Per CIDRAP. The four phases Forced to sell.
what’s happening: Antibiotics are being thrown in COVID-19 patients Growing research Refers to secondary infections such as Sepsis, So responsible Because of part of the death.
- We don’t have enough data to determine if they had an AMR infection, but we’re very worried that increased drug use could lead to greater resistance, says the infectious disease of Biotechnology Innovation Organization, a biotechnology trade organization. Says policy director Greg Frank.
- In many cases, viruses weaken the body’s immune system and make it more susceptible to bacterial infections. And some of the methods used to save patients- Ventilation — Frank can also expose people to other bacteria, says Frank.
- this is More calls to test patients For bacterial and fungal infections with COVID-19.
- Frank also said that authorities would eventually put “missions” in order to focus resources on only direct issues, such as finding treatments and vaccines for COVID-19, and to cause people to die of secondary infections. I failed. ” .
The point: “A complete and effective stockpile of antibiotics, antibacterial and antifungal agents is a key factor in preparing for the next pandemic,” Frank tells Axios.
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