Health
Pangolin holds a clue as to how COVID-19 started, and may end
Friday, May 08, 2020 (HealthDay News) -They are small spiny mammals that look like anteaters with scales.
And Pangolins-believed to play a role in the emergence of the new coronavirus-may hold clues to fighting COVID-19.
New coronavirus genetic studies have discovered a pathway to pangolins derived from bats and sold in the Chinese “wet market,” and then transferred to humans.
So why doesn’t the virus get sick and kill the pangolin?
In a new study, researchers at the Medical University of Vienna, Austria, analyzed the ginkgo blueprint and compared it with other mammals, including humans, cats, dogs, and cows.
In most mammals, certain genes detect when the virus has entered the body and trigger an immune response to the invader.
But ginseng lacks two of these virus-sensing genes, the team reported in the May 8 issue of the journal. Immunology frontier. It’s unclear if the difference protects creatures from COVID-19, but more research is needed.
Austrian scientists believe this finding is important in the sense that while Pangolin can be a carrier of the new coronavirus, there may be ways to reduce its annoying effects .
The team may suggest possible treatments for human coronaviruses by learning more about this evolutionary advantage of pangolins, he said.
“Our study shows that Pangolins survive the millions of years of evolution of the antiviral defense-free type used in all other mammals.”
“Further studies on pangolins will reveal how they survive viral infections, and this may help devise new therapeutic strategies for people with viral infections,” Eckert added. It was
In humans, the new coronavirus causes an inflammatory immune response called the cytokine storm, which causes more serious illness.
Eckhart said the over-activated immune system can be mitigated “by diminishing strength or altering the timing of defense responses.”
Therefore, drugs that suppress gene signaling could represent a potential treatment option for severe cases of COVID-19, Eckert said. But there is a problem. Immunosuppressive drugs can make patients more vulnerable to other infections.
So, “the main challenge is to reduce the response to pathogens while maintaining adequate control of the virus,” Eckert said.
For more information
The Centers for Disease Control and Prevention COVID-19 (New Coronavirus Infection) (# If there is no character limit, add parentheses when first appearing.
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