Columbia University study It was found that the memory of COVID-19 infection released on October 7 was mainly conserved in T cells and B cells in the lungs and surrounding lymph nodes.
Prior to the release of the vaccine, the researchers studied the tissues of four COVID-19 survivors aged 11-74 years who died from unrelated causes and compared them to the tissues of uninfected individuals.
The study found that older people also had “strong” immunological memory of the new pathogen, even though the immune system did not produce T cells after age 40.
“We know that the immune system declines with age,” said George H. Humphreys II, a professor of surgical science and a professor of microbiology and immunology at Columbia University’s Bageros Medical Surgery University. Dr. Dona Faber said. “But the fact that someone in their 70s was able to produce a robust and long-lasting immunological memory response shows that there is still a portion of the immune system that we relate to younger age.”
Researchers have also found evidence that a special site called germinal center is present in lung-related lymph nodes in the elderly for up to 6 months after infection.
“Our study suggests that vaccines should target memory immune cells in the lungs and associated lymph nodes to improve protection against the virus. This is a damaging virus. Can be achieved with nasal drops, “Farber said. “It was previously known that influenza mice require lung memory T cells for optimal protection against respiratory infections. The same study may apply to people. Strongly suggests. ”
Researchers are now examining the tissues of vaccinated donors to see if vaccine-induced memories are similar to those created by natural infections.
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