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Safety of SARS-CoV-2 Vaccine in Biopharmacy-treated Psoriasis Patients: Practical Experience-Maria Letizia — Dermatological Treatment

Safety of SARS-CoV-2 Vaccine in Biopharmacy-treated Psoriasis Patients: Practical Experience-Maria Letizia — Dermatological Treatment

 


Vaccination is the most effective way to prevent and control SARS-CoV-2 infection, and biologics are not considered contraindicated for vaccination. There is a serious problem of lack of safety data as patients taking drugs that affect the immune system have been excluded from clinical trials leading to vaccine approval. In addition, vaccination seems to be able to exacerbate psoriasis. A study was conducted to investigate the safety of the SARS-CoV-2 vaccine in patients with psoriasis treated with biopharmacy. A total of 150 patients with stable psoriasis vulgaris treated with biopharmacy for at least 2 months were evaluated over a 3-month period. Fifty patients (22 F / 28 M; age: 33-83 years) received only the first and second doses of SARS-CoV-2 vaccine. All patients discontinued the biologic 10 days before and 10 days after each dose of vaccine. Of these, 24 patients were treated with anti-TNF, 14 were treated with anti-IL17, 7 were treated with anti-IL12-23, and 5 were treated with anti-IL23. On days 2, 7, and 14 days after vaccination, all patients were evaluated for local and / or systemic side effects and / or side effects to the SARS-CoV-2 vaccine. None of the patients experienced side effects or psoriatic redness. Only one patient treated with infliximab biosimilars mentioned exacerbation of psoriasis after vaccination. The remaining 100 patients reported that they had not yet been vaccinated. Our preliminary data confirm that the SARS-CoV-2 mRNA vaccine is safe for patients with chronic psoriasis vulgaris treated with biopharmacy and did not cause psoriasis, but these data Should be validated in a larger population. Early administration of the SARS-CoV-2 vaccine is recommended for all psoriasis patients taking immunosuppressants.

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2/ https://onlinelibrary.wiley.com/doi/abs/10.1111/dth.15177

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