Health
Problems of metal metabolism in childhood associated with the development of ALS in adulthood
Adults with Lugeric’s disease (ALS) may have had problems metabolizing certain metals in childhood, according to scientists who studied teeth in patients with degenerative diseases.
Symptoms usually first appear in your 50s or 60s. It is characterized by the death of nerve cells and causes patients to lose their motor skills. Ultimately, it leads to paralysis. In most cases, the cause is unknown, but it is thought that genetic factors and environmental factors are involved.
Author of a paper published in a journal to investigate potential links between specific metals and diseases Clinical annual report and Translation Neurology, Examined the teeth ALS 31 unaffected patients and controls. With permission, they studied teeth from autopsy or extraction. The laser was used to measure the levels of essential nutrients and toxic metals in tooth markings comparable to tree rings. This allowed scientists to graph metal intake for each person during childhood.
The levels of metals such as chromium, nickel, tin and zinc are ALS Patient vs. control. Similar analysis in mice with similar conditions ALS Validated their findings. In mice, the team also found differences in metal distribution in the brain, suggesting a link between these substances and ALS.
Co-author mannish Arora, A professor of environmental medicine and public health at Ikhan Medical University on Mount Sinai, Newsweek: “This study shows that metal Dysregulation Associated with the onset of decades, during certain periods of childhood and early adolescence ALS“
Arora “Our team has been interested in the overall trajectory of brain health for over a decade. ALS It’s a very difficult disease to study, because I’m not sure what causes it. Scientists suspect that several environmental factors in childhood are at work, but so far no technology is available to identify those factors. “
Christine Austin, associate professor of environmental medicine and public health at Ikhan School of Medicine on Mount Sinai, who co-authored the paper, Newsweek Teeth are “one of the only tissues in the body that archives information about childhood and stores it for later analysis.”
She said: “The most interesting finding is that biochemical pathways are disrupted early in birth and childhood because of clinically manifesting conditions in the 50s and 60s after birth.”
Limited research due to small sample size and participants coming from the same research center Arora “But similar results from ALS mouse The model is promising. “
The team expects the findings to lead to ways to predict risk ALS Austin said in the baby’s teeth after they dropped out. “This means that they could potentially intervene through the treatment of metals and prevent the development of the disease. Dysregulation“
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