Health
First patient vaccinated in a clinical trial of an HIV vaccine using Moderna’s mRNA technology
The first participants were vaccinated in a Phase 1 clinical trial of an HIV vaccine utilizing Moderna’s mRNA technology. announcement last week.
The exam, titled IAVI G002, is being conducted in collaboration with IAVI, a non-profit scientific research institute. We are testing vaccines that deliver HIV-specific antigens into the body with the aim of inducing an immune response. These antigens were initially developed by researchers at IAVI and Scripps Research, led by Dr. William Seef.
In last year’s “proof-of-concept” trial, the researchers found that HIV antigens produce the desired immune response in 97% of participants. The current trial is based on previous trials by testing the primary and booster versions of the vaccine and adopting Moderna’s mRNA technology that was previously used to create the successful COVID-19 vaccine.
“We are very excited to use Moderna’s mRNA platform to advance this new direction in the design of HIV vaccines. Searching for HIV vaccines has long been difficult and has new tools on immunogens and platforms. That could be the key to making rapid progress, towards an urgently needed and effective HIV vaccine, “said Mark Feinberg, president and CEO of IAVI, in a news release from Moderna. Said in.
A new trial, partially funded by the Bill & Melinda Gates Foundation, will track 56 HIV-negative adult participants with the goal of studying both the safety and efficacy of the vaccine. Forty-eight volunteers receive at least one primary vaccine, 32 of whom also receive booster immunity. The remaining 8 people will only be vaccinated with the booster vaccine.
The trial includes participants from four locations: George Washington University School of Medicine, Hope Clinic at the Emory Vaccine Center, Fred Hutchinson Cancer Research Center, and San Antonio Health Science Center at the University of Texas.
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