Reversal of Aging: Scientists Rejuvenate Middle-aged Mouse Tissues | Chemistry

After scientists safely rejuvenate the tissues of middle-aged mice, the prospects for medical therapy to rewind the clock of the aging process are a little closer.

Researchers in the United States have treated healthy animals in the form of gene therapy that refreshes old cells, making them more youthful, according to biological markers used to measure the effects of aging.

Repeating this trick in humans is not an easy task, but the discovery aims to slow or reverse the aging process as a means of addressing age-related diseases such as cancer, bone fragility, and Alzheimer’s disease. Raises interest in radical new treatments.

“Many age-related diseases can benefit from this approach,” said Heinrich Jasper, senior researcher and director of US biotechnology company Genentech.

If this approach can be shown to combat specific health problems, “it will constitute a new therapeutic approach that will have a significant impact on unmet medical needs at all stages of our lives,” he said. I added.

Scientists have used a previous study by Professor Shinya Yamanaka, a Japanese Nobel laureate, to allow a mixture of four molecules known as the Yamanaka factor to form adult cells into almost any tissue in the body. It has been shown that it can be rewound into various stem cells.

Write in the journal Nature agingThe US team, led by Professor Jasper and Juan Carlos Ispis Abelmonte of the Salk Institute for Biological Studies and the San Diego Altos Institute in California, found that mice that received the Yamanaka factor for several months were young animals in many respects, especially in the skin and kidneys. Found similar to, showing signs of rejuvenation.

Experiments have shown that rejuvenation is more effective when animals are 12 to 15 months old, that is, when they are treated for a long period of 7 to 10 months, which is equivalent to 35 to 50 years for humans. .. Scientists saw little effect when animals older than 80 years old in the human sense were treated for a month.

Previous studies have shown that fully reprogrammed cells can turn into a mass of cancerous tissue called a teratoma, so researchers pay attention to the use of the Yamanaka factor in humans. I am.

Recent research shows that partial reprogramming may be able to rejuvenate an organization without such risks, but additional hurdles remain. Many scientists suspect that new drugs may be needed to safely and effectively partially reprogram cells, rather than using the Yamanaka factor to rejuvenate older people.

“Can this be applied to humans?” Said Dr. Tamir Chandra, an expert in aging biology at the University of Edinburgh who was not involved in the study.

“Theoretically, it is possible to reverse or reduce the biological age, but we are in the very early stages and need a better understanding of the underlying science behind it. ..

“Using the Yamanaka factor carries the risk of inducing cancer. Unlike mice, humans have a long lifespan, so they can mutate more and become more likely to develop cancer as they get older.

“The research group is working on the timing, dosage, and combination of Yamanaka factors to minimize this risk.

“Since we have found that cell identity loss and age reversal can be distinguished by their trajectory, other groups are trying to find new factors that separate cell identity loss from the rejuvenation effect.

“The first application could be in a tissue that is easily accessible and modifiable outside the body, such as blood stem cells.”

What Are The Main Benefits Of Comparing Car Insurance Quotes Online

LOS ANGELES, CA / ACCESSWIRE / June 24, 2020, / Compare-autoinsurance.Org has launched a new blog post that presents the main benefits of comparing multiple car insurance quotes. For more info and free online quotes, please visit https://compare-autoinsurance.Org/the-advantages-of-comparing-prices-with-car-insurance-quotes-online/ The modern society has numerous technological advantages. One important advantage is the speed at which information is sent and received. With the help of the internet, the shopping habits of many persons have drastically changed. The car insurance industry hasn't remained untouched by these changes. On the internet, drivers can compare insurance prices and find out which sellers have the best offers. View photos The advantages of comparing online car insurance quotes are the following: Online quotes can be obtained from anywhere and at any time. Unlike physical insurance agencies, websites don't have a specific schedule and they are available at any time. Drivers that have busy working schedules, can compare quotes from anywhere and at any time, even at midnight. Multiple choices. Almost all insurance providers, no matter if they are well-known brands or just local insurers, have an online presence. Online quotes will allow policyholders the chance to discover multiple insurance companies and check their prices. Drivers are no longer required to get quotes from just a few known insurance companies. Also, local and regional insurers can provide lower insurance rates for the same services. Accurate insurance estimates. Online quotes can only be accurate if the customers provide accurate and real info about their car models and driving history. Lying about past driving incidents can make the price estimates to be lower, but when dealing with an insurance company lying to them is useless. Usually, insurance companies will do research about a potential customer before granting him coverage. Online quotes can be sorted easily. Although drivers are recommended to not choose a policy just based on its price, drivers can easily sort quotes by insurance price. Using brokerage websites will allow drivers to get quotes from multiple insurers, thus making the comparison faster and easier. For additional info, money-saving tips, and free car insurance quotes, visit https://compare-autoinsurance.Org/ Compare-autoinsurance.Org is an online provider of life, home, health, and auto insurance quotes. This website is unique because it does not simply stick to one kind of insurance provider, but brings the clients the best deals from many different online insurance carriers. In this way, clients have access to offers from multiple carriers all in one place: this website. On this site, customers have access to quotes for insurance plans from various agencies, such as local or nationwide agencies, brand names insurance companies, etc. "Online quotes can easily help drivers obtain better car insurance deals. All they have to do is to complete an online form with accurate and real info, then compare prices", said Russell Rabichev, Marketing Director of Internet Marketing Company. CONTACT: Company Name: Internet Marketing CompanyPerson for contact Name: Gurgu CPhone Number: (818) 359-3898Email: [email protected]: https://compare-autoinsurance.Org/ SOURCE: Compare-autoinsurance.Org View source version on accesswire.Com:https://www.Accesswire.Com/595055/What-Are-The-Main-Benefits-Of-Comparing-Car-Insurance-Quotes-Online View photos