How Sugar-Free Foods Impair Liver Detoxification Ability

Published: Updated-9:16 pm, Sunday-April 10-22

new york: According to one study, ingestion of sugar-free foods and beverages such as yogurt and diet soda can impair the ability of the liver to excrete toxins, which can be unhealthy, as expected.

The study, led by a team at Wisconsin Medical College in the United States, examined two sugar alternatives, also known as non-nutritive sweeteners, acesulfame potassium and sucralose, and provided a sweet taste with few or no calories.

They disrupt the function of proteins that play important roles in liver detoxification and metabolism of certain drugs.

“Many people are unaware that these sweeteners are found in light or zero sugar versions of yogolds and snack foods, as well as non-foods such as chemicals and certain cosmetics,” the Medical Association said. Laura Danner, a doctoral student, said. ..

In this study, the team found that acesulfame potassium and sucralose inhibit the activity of P-glycoprotein (PGP), also known as multidrug-resistant protein 1 (MDR1). PGP is part of a family of transporters that work together to purify the body of toxins, drugs, and drug metabolites.
Dr. Stephanie Olivier van Stichelen, who heads the research team, said:

“As far as we know, we are the first group to decipher the molecular mechanisms by which non-nutritive sweeteners affect liver detoxification.”

Experiments also show that sweeteners stimulate transport activity and possibly bind to PGP, thus competing with xenobiotic, drugs and their metabolites, short chain lipids, and other substrates such as bile acids and inhibiting transport. Showed to do.

Researchers warn that this study is preliminary and needs to be confirmed in preclinical and clinical studies, but findings show that they are taking medications that use PGP as their primary detoxification transporter. It suggests that non-nutritive sweeteners can be a problem for people who are. These include certain antidepressants, antibiotics, and blood pressure medications.

“If future studies confirm that non-nutritive sweeteners impair the body’s detoxification process, it is imperative to study potential interactions and determine safe consumption levels for risky groups. “Danner said. “It may also be important to include certain amounts of non-nutritive sweeteners on food labels so that people can more accurately track their intake.”

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