Health
Studies provide a framework for understanding how memory T cells present in tissues adapt to different environments.
Scientists exploring how our immune system responds to pathogens and cancers are paying more attention to CD8.+ T cellsDeployed in response to infections and malignant tumors, it is equipped to remember the identity of malicious intruders.
Some of these important “memory” cells circulate throughout the body, while others remain within the body’s organs to protect the site of entry as part of an established long-term defense system. Is known.A new biologist-led study at the University of California, San Diego provides fresh insights into these specialized cells known as CD8.+ Memory T cells present in tissues. Released on June 27 Nature immunologyThis study was led by postdoctoral fellows Maxheag and John Klaul (now an out-pace bioscientist) in the laboratory of Professor Ananda Goldras in the Department of Biological Sciences at the University of California, San Diego. It provides a framework for understanding how cells adapt to different things. Tissue environment. Researchers have developed a new atlas that describes memory T cells present in tissues in diverse tissue environments, driving the prospect of developing immune defense strategies that enhance immunity at sites vulnerable to infection. ..
Strategic design of vaccines that provide maximum protection between pathogens and tissue “first responders” where tumors begin to grow by identifying unique transcriptional pathways and regulators of memory T cells present in tissues. Discover new informative targets. “
Professor Ananda Goldras, Professor Donated by Prime Minister Tata, Department of Molecular Biology
Some studies examined memory cells as they circulate or settle in organ tissue, but little is known about the role of the surrounding tissue environment in the process.Once the infection has settled, the immune system activates CD8+ Induce T cells to infected tissue and investigate the cells for pathogens.Number of pathogen-specific CD8s once infection is resolved+ Although T cells are depleted, a small number of cells remain as a type of long-term sentry system to strengthen immunity to future infections.
A new study examined memory T cells in tissues found in mouse organs such as the kidney, spleen, small intestine, and liver. Collective results from all of these different tissue environments have generated insights into how each T cell population is dominated by a unique process based on “resident tissue.”
Finally, scientists raise the possibility that future extensions of this study will come in the form of customized engineering therapies. Transcriptionally designed for transport, retention, and function within a particular tissue. “
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Journal reference:
Crowl, JT, et al. (2022) Memory CD8 existing in the tissue+ T cells have unique transcriptional, epigenetic, and functional adaptations to different tissue environments. Nature immunology. doi.org/10.1038/s41590-022-01229-8..
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