Health
Research finds that hydroxychloroquine helps improve survival in coronavirus patients
A team of 2,541 inpatients on Thursday found that a group of people receiving hydroxychloroquine were far less likely to die, a team from the Henry Ford Health System in southeastern Michigan said Thursday. ..
Dr. Marcus Selbos, head of the Infectious Diseases Department at Henry Ford Health System, said that 26% of those who did not receive hydroxychloroquine died while 13% of those who got the drug died. I said. The team looked back at everyone treated in the hospital system since the first patient in March.
This is a surprising finding, as some other studies did not find any benefit from hydroxychloroquine, a drug originally developed to treat and prevent malaria. President Donald Trump touted the drug strongly, but subsequent research showed that not only did the drug not improve the patient’s effect, but he was also likely to suffer from side effects of the heart. understood.
Earlier this month, the US Food and Drug Administration revoked the drug’s emergency use permit and suspended worldwide testing, including testing sponsored by the World Health Organization and National Institutes of Health.
“Our results differ from some other studies,” Zelbos said at a press conference. “What was important to us was that the patient was treated early. In order for hydroxychloroquine to be beneficial, some of the serious immune reactions that patients may have with Covid Before you get sick, you need to start hydroxychloroquine.” Added.
Henry Ford’s team also carefully monitored patients for heart problems, he said.
“The combination of hydroxychloroquine and azithromycin was reserved for selected patients with severe COVID-19 and minimal cardiac risk factors,” the team writes.
Henry Ford’s team said they believe they have discovered that hydroxychloroquine may be potentially useful as a treatment for coronaviruses.
“In the right situation, it’s important to note that this can be a lifesaver for patients,” said Dr. Stephen Carcanis, CEO of Henry Ford Medical Group, at a press conference. Told.
Calcanis said their findings were not necessarily consistent with those of previous studies. “I would also like to point out that those studies are not wrong or clearly contradictory because our results differ from some other results that may have been published. What it simply means, by examining its subtle data, patients may actually benefit and may be able to further elucidate the code as to when and how this disease works. “He said.
“More work needs to be done to figure out the final treatment plan for Covid-19,” added Karcanis. “But I feel these are very important consequences. If there was a second surge, and in other relevant parts of the world, we need to add to the combination of ways we move forward. This helps people fight this illness and mortality.”
Zelvos said hydroxychloroquine can help interfere with the virus directly and can also reduce inflammation.
Researchers who were not involved in the study were important. They noted that the Henry Ford team did not randomly treat patients, but chose patients for different treatments based on specific criteria.
The Henry Ford team writes that 82% of patients received hydroxychloroquine within 24 hours of admission and 91% within 48 hours after admission.
By comparison, a study of patients in 25 hospitals in New York wrote that the drug was started “at any time during hospitalization.”
“Maybe there’s a slight difference, but it doesn’t seem like New York patients started on day 7. It’s not what happened,” says New York study lead author Albany Public Health. School college.
Rosenberg also noted that the Detroit paper excluded 267 patients (nearly 10% of the study population) who were not yet discharged from the hospital.
This could distort the results and make hydroxychloroquine look better than it really is, he said. Those patients were so ill that they could still be in the hospital, and when they died, when they were excluded from the study, hydroxychloroquine appeared more life-saving than they really were.
He also told CNN, “In all this, there is a slight tingling sensation.”
Both the Detroit and New York studies were observable. The doctor looked back at what the patient was doing when prescribing hydroxychloroquine.
Observational studies are informative, but not as valuable as controlled clinical trials. Regarded as the gold standard of medicine, patients in clinical trials are randomly assigned to take either drug or placebo. This is a treatment that does nothing. The doctor then tracks the patient to see how they are progressing.
Two clinical trials of Covid-19’s hydroxychloroquine, one in the United States and another in the United Kingdom, were discontinued early because it suggested that hydroxychloroquine was useless.
A UK study run by Oxford University enrolled more than 11,000 patients.
However, White House officials commended the Henry Ford team’s work.
Peter Navarro, a White House trade adviser, said the study showed that hydroxychloroquine could work if given early enough.
“This is a big deal,” he told CNN. “This drug can literally save tens of thousands, perhaps hundreds of thousands of American lives and perhaps millions of people worldwide.”
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