Genetic susceptibility to COVID-19 may increase risk of hypothyroidism

August 3, 2022 Read in 2 minutes Source/Disclosure The issuer: Disclosure: The authors report no relevant financial disclosures. Add topic to email alert Get an email when new articles are posted Enter your email address to receive an email when new articles are posted . " data-action"subscribe"> Subscribe Your request could not be processed. Please try again later.If this issue persists, please contact us customerservice@slackinc.com. back to helio Adults with genetic susceptibility to COVID-19 infection are: hypothyroidismaccording to findings from a Mendelian randomization published in thyroid. "Host genetic susceptibility to SARS-CoV-2 infection is associated with increased risk of overt and subclinical hypothyroidism." Dr. Ching-Lung CheungAssociate Professor, Department of Pharmacology and Pharmacy, Li Ka Shing School of Medicine, University of Hong Kong, and Gloria Huiyi Lee doctorateAn assistant professor in the Department of Medical Technology and Informatics at the Hong Kong Polytechnic University told Helio: “Conversely, a genetic predisposition to thyroid-related traits is associated with SARS-CoV-2 infection and COVID-19 results" Source: Adobe Stock The researchers collected data from the largest meta-analysis of genome-wide association studies. A two-way Mendelian randomized study was performed to assess the association with her COVID-19 phenotype with thyroid-related traits. Forward, researchers assessed whether her COVID-19 phenotype was causally related to thyroid traits. Conversely, researchers analyzed whether genetically determined thyroid traits were causally related to her COVID-19 phenotype. The main analysis was performed using the conventional inverse variance weighting method. Sensitivity analyzes were performed using median weight, Mendelian randomized–Eger regression, contaminated mixtures, Mendelian randomized multifaceted residual sums and outlier tests for outlier methods. Chan Ching Long In the main analysis, genetic susceptibility to SARS-CoV-2 infection was associated with an increased risk of hypothyroidism (OR 1.335; 95% CI, 1.167-1.526). Sensitivity analyzes using outlier tests and outlier methods of median weight, Mendelian randomized Eger regression, contamination mixtures, and Mendelian randomized multifaceted sums of residuals also demonstrated genetic susceptibility to SARS-CoV-2 infection. Every doubling was found to increase the risk of hypothyroidism. "Host genetic responsibility for SARS-CoV-2 infection may increase the lifetime risk of overt and subclinical hypothyroidism," Cheung and Li said. It may be beneficial to be able to arrange thyroid function monitoring and timely treatment for individuals previously infected with SARS-CoV-2 if they are aware of this. It may reduce the risk of hypofunction." No association was observed between genetic susceptibility to hyperthyroidism, hypothyroidism, autoimmune thyroid disease and the COVID-19 phenotype. Genetically determined thyroid-stimulating hormone and free thyroxine levels were within reference ranges, TSH was within full range, and were not associated with the COVID-19 phenotype. Cheung and Li said prospective studies are needed to collect additional data on long-term thyroid function in adults with COVID-19. “Additionally, long-term COVID and hypothyroidism have some common symptoms, such as fatigue, cognition, and mood problems,” said Cheung and Li. Long-term studies are needed to investigate the possible association of For more information: Dr. Ching-Lung Cheungcan access lung1212@hku.hk. Gloria Hoi-Yee Li, PhDcan access gloria-hy.li@polyu.edu.hk. Add topic to email alert Get an email when new articles are posted Enter your email address to receive an email when new articles are posted . " data-action"subscribe"> Subscribe Your request could not be processed. Please try again later.If this issue persists, please contact us customerservice@slackinc.com. back to helio COVID-19 Resource Center Sources 1/ https://Google.com/ 2/ https://www.healio.com/news/endocrinology/20220802/genetic-susceptibility-to-covid19-may-increase-risk-for-hypothyroidism The mention sources can contact us to remove/changing this article