Health
Docetaxel: Chemotherapy Drugs Possibly Less Effective in Breast Cancer Overweight, Obese Women-Health
According to the new, treatment with the common chemotherapeutic drug docetaxel may not provide much benefit for overweight or obese breast cancer patients the study..
International team researcher This conclusion is based on a retrospective analysis of data from large clinical trials. Their study was published in the Journal of Clinical Oncology.
In most European countries, more than 50% of women are overweight or obese (body mass index (BMI) is above 25 kg/m2 by WHO definition). In the United States, this applies to more than 63% of women, and this percentage is expected to increase further over the next few years.
Although it is not widely known, obese women are at increased risk of developing breast cancer and obese breast cancer patients are at increased risk of relapse. In addition, many cancer patients are overweight or obese, but the efficacy of anticancer drugs with BMI is not generally known.
In this study, a team led by researchers at KU Ruben and Institut Jules Bordet (Belgium), University of Milan, and the National Cancer Institute (Italy) analyzed data from clinical trials involving more than 2800 breast cancer patients. did. The turning point of the Millennium.
Patient data has been collected for over 10 years. Patients in this trial were treated with a combination of chemotherapeutic agents, with or without one of the world’s most widely used chemotherapeutic agents, docetaxel. The researchers then looked at how many patients had recurred and how many died.
A statistical analysis of the data showed that overweight and obese patients who received docetaxel as part of their treatment had poorer outcomes than lean patients (BMI 18.5-25 kg/m2). This difference was not observed in patients who received chemotherapy regimens that did not include docetaxel.
“Docetaxel is a lipophilic drug, suggesting that the fats present in the body may absorb some of the drug before it reaches the tumor,” says KU for translational breast cancer research. Explained Professor Christine Desmet of the Reuben Institute.
This result raises concerns regarding the treatment of overweight and obese cancer patients with docetaxel.
“If follow-up studies confirmed that this finding was only associated with the pharmacological properties of docetaxel, it would also apply to patients with other types of cancer treated with docetaxel, such as prostate and lung cancer.” That may be true. These results also wonder if other chemotherapeutic agents from the same family, such as paclitaxel, would have the same effect,” Desmet explained.
Professor Desmet also said: “To implement treatment changes, more research is needed. Patients who are concerned about docetaxel can discuss these with their doctors. Generally, the link between BMI and breast cancer is more You need to know it well.”
“In the world of medicine and research, more attention needs to be paid to how obesity affects the biology, progression, and treatment of breast cancer. There is still a lot of work to do in this area,” Milan said. Professor Bigangozoli at the University School of Medicine and Data Science Research Center, University of Milan and the Italian Cancer Institute.
(This article was published without modification from the text of the telegraph agency’s feed. Only the heading has changed.)
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