Health
New Zika vaccine technology found to be highly effective and safe in preclinical mouse models
Researchers at the University of California, Los Angeles (UCLA) have developed a highly effective and safe Zika vaccine technology in a preclinical mouse model. In a mouse model of pregnancy, the vaccine prevented both the pregnant mother and the developing fetus from developing systemic infection. microbiology spectrumJournal of the American Society for Microbiology.
The vaccine design involved deleting a portion of the Zika genome that encodes the viral shell. This modification stimulates an immunogenic response and prevents the virus from replicating and spreading from cell to cell. ”
Vaithilingaraja Arumugaswami, DVM, Ph.D., Associate Professor of Molecular Medicine and Pharmacology, UCLA
Vaccinated mice showed elevated levels of cellular immune responses in the form of increased effectors T cells population compared to unvaccinated mice. Researchers have also tested the vaccine in various other mouse models and found it to be safe and protective.
The impetus for this work was the 2016 Zika virus outbreak. The virus spread rapidly in the Americas, affecting millions of people and causing severe socioeconomic hardship. Zika virus is the first mosquito-borne virus to demonstrate the ability to affect human reproduction.
To date, there is no vaccine or other treatment approved for Zika virus. Research into other ways to fight the virus has also apparently not led to effective measures. “However, given the rapid evolution and tendency of RNA viruses (the category to which both the Zika virus and the SARS family of viruses belong), it is likely that more outbreaks will occur in the near future. .
The average duration of large-scale spread of the Zika virus is about seven years. “It’s only a matter of time before the virus starts spreading again,” said Hiroki Morizono, M.D., Ph.D., associate professor of medicine at UCLA and co-lead author of the study.
Worse, climate change is expanding acceptable habitats for mosquitoes. egyptian templetransmit the Zika virus to humans, increasing the population at risk.
“The ongoing COVID-19 pandemic has shown us the power of strong pandemic planning and clear communication on prevention methods, all of which has led to the rapid deployment of a safe and reliable vaccine,” said Arumugaswami. says Mr. It is therefore imperative to develop a strong pandemic preparedness plan. “Our study is an important first step towards developing an effective vaccination program that can control the spread of Zika virus and prevent large-scale outbreaks from occurring,” said Almugaswamy. .
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Journal reference:
Garcia Jr., G. and others. (2022) A replication-defective Zika vector-based vaccine provides maternal and fetal protection in a mouse model. microbiology spectrum. doi.org/10.1128/spectrum.01137-22.
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