Health
Orally ingestible robotic drug delivery device overcomes gastrointestinal environmental barriers
Oral drug delivery is the most popular and cost-effective method for providing therapy. However, before a drug can be absorbed, it must pass through the harsh acidic environment of the stomach, resist degradation by enzymes, cross the barrier provided by the mucus of the small intestine, and overcome many other obstacles. Because of these challenges, many drugs, including common drugs such as insulin, must be administered by other means.
Researchers at Brigham and Women’s Hospital, a founding member of the Mass General Brigham Healthcare system, and MIT have developed RoboCap, an orally ingestible robotic drug delivery device that overcomes many challenges of the gastrointestinal environment to deliver payloads. Developed. The team tested the device in preclinical models using insulin and vancomycin, antibiotics usually given intravenously. When ingested, RoboCap’s gelatinous coating dissolves in the stomach. The small intestine environment activates RoboCap. The RoboCap vibrates and rotates to dislodge mucus, promote mixing, and deposit the drug payload in the small intestine where drug is readily absorbed. In a swine model, RoboCap increased drug permeability of both insulin and vancomycin more than 10-fold.
“Peptides and proteins are important drugs, but the degradation environment and malabsorption of the gastrointestinal tract limit the ability to deliver these drugs orally,” said co-corresponding author C. Giovanni Traverso, MB. BChir, PhD said. Gastroenterology, Hepatology, and Endoscopy at Brigham University, and Mechanical Engineering at MIT. “RoboCap’s mucus removal and agitation movements are designed to help overcome these barriers and deliver the drug where it is needed.”
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