Health

COVID-19 infection increases the risk of diabetes diagnosis in pediatric patients

Six months after COVID-19 infection, 123 patients were diagnosed with type 1 diabetes (T1D), and only 72 were diagnosed with T1D six months after non-COVID-19 respiratory infections. .

New type 1 diabetes (T1D) diagnoses are more likely to occur in previously diabetic pediatric patients. COVID-19 infection than patients with other respiratory infections, according to a study published in JAMA network open.

Additionally, researchers said the risk of T1D in people with previous COVID-19 is higher than in other healthcare system encounters. According to this study, respiratory infections have previously been associated with the development of he T1D.

Investigators included 314,917 patients with COVID-19 and 776,577 patients with respiratory infections other than COVID-19. They matched the cohort to include 285,628 patients with COVID-19 and the same number of patients with respiratory infections other than COVID-19.

Six months after COVID-19 infection, 123 patients were diagnosed with T1D, and only 72 were diagnosed with T1D 6 months after non-COVID-19 respiratory infection.

At 1, 3, and 6 months after infection, people infected with COVID-19 had a higher risk of being diagnosed with T1D compared with other respiratory infections. This result also applied to the 0-9 year old subgroup and he 10-18 year old subgroup.

Researchers found similarly elevated risks, including fractures and pediatric visits, in pediatric patients infected with SARS-CoV-2 compared to other control cohorts at 6 months.

For this study, researchers used data from the TriNetX analytics platform. This is his database of over 90 million individual anonymized electronic health records (EHRs) from the Global Collaborative Network, which includes 74 large medical institutions and 14 major medical institutions across the United States. Countries with different geographic, racial, age, income, and insurance backgrounds.

The population included pediatric patients divided into two cohorts. same period.

The cohort was divided into two groups, 0-9 years old and 10-18 years old.

Cohorts were matched 1:1 with the closest greedy matching for demographics and individual family history of diabetes.

They also compared the risk of receiving a new diagnosis of T1D within 1, 3, and 6 months after infection between matched cohorts. Investigators performed statistical analysis using the TriNetX analysis platform. Researchers used hazard ratios and 95% confidence intervals to compare diagnostic rates between study groups and subgroups.

Study limitations include potential biases of observational studies using the EHR, such as the possibility of misclassifying diabetes as type 1 or type 2.

Additionally, additional unidentified factors may have contributed to the association. The researchers say the results should be confirmed in other populations, but these results are important considerations for the risk-benefit debate for COVID-19 prevention and treatment in the pediatric population. .

reference

Kendall EK, Oraker VR, Kerber DC, Shue R, Davis PB. Association between SARS-CoV-2 infection and new-onset type 1 diabetes in pediatric patients from 2020 to 2021. JAMA net open2022;5(9):e2233014.doi:10.1001/jamanetworkopen.2022.33014

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COVID-19 infection increases the risk of diabetes diagnosis in pediatric patients