Health
A potential new cure for ‘Long Covid’ has been discovered.read here
Long Covid remains a potentially fatal infection, and patients suffering from acute Covid infection may continue to suffer symptoms despite negative test results. A team of scientists from the University of Miami, USA, has discovered a potential treatment that could save lives.
The study reveals a new approach to providing treatment to patients suffering from severe illness. Long-term Covid symptomsIt should be noted that patients suffering from long Covid symptoms often report death from organ failure.
The research team found that placing a peptide “net” around the viral spike protein reduced deaths from organ failure and also improved overall outcomes. It uses proteins to enter and infect cells.
“Despite advances in vaccines, a significant proportion of infected patients develop long-term problems in the brain, lungs, heart, liver, or kidneys,” said the study’s lead author, published in the journal Molecular Neurobiology. Researcher Michael J. Paidas said.
“Our laboratory’s research SARS-CoV-2 virus From finding potential cures for infected individuals to attach themselves to cells and fight the lasting effects of Covid.
According to the researchers, this is the first study to follow laboratory animals for a long period of time and identify pathological changes in the brain, heart and other organs in mice, which would take years in humans.
“Twelve months after these mice were infected with the coronavirus model, we observed pathological changes in multiple organs and blood vessels,” said research assistant professor Arumugam R Jayakumar.
“However, treating infected mice with a small synthetic peptide, patented as SPIKENET, interfered with the binding of the spike protein, which could lead to disease progression and its spread to the brain, heart, lungs, and other organs.” Pathological changes have been significantly reduced,” Jayakumar said.
He added that the Covid long-term study results are consistent with the research team’s previous work on the acute phase of Covid infection.
the underlying mechanism is SARS-CoV-2The immune system’s inflammatory response can lead to edema, a rapid accumulation of fluid within cells that damages tissues and organs.
“Using our mouse model, we found that SPIKENET treatment improved cellular inflammatory and oxidative stress responses during the acute phase of infection,” said Paidas.
“We also discovered that SPIKENET works through a new mechanism by altering aquaporins, key water channels present in cells throughout the body,” he said.
Researchers found that SPIKENET reduced edema and resulted in better outcomes through these three key mechanisms.
“SPIKENET offers a one-two punch and we believe it will be an attractive therapeutic,” said Paidas.
“By preventing the virus from entering cells and limiting the damage caused by the virus, we return the organ to a more normal physiological state,” he added.
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