Demand for Diabetes Drugs Leads to Shortages

Ozempic, a prescription drug to treat type 2 diabetes, has received a lot of attention for one of its side effects. weight loss.

A social media sensation, the topic “Ozempic” has over 300 million views on TikTok.Mostly used by non-diabetics Unauthorized — took approved medication for unapproved use and acknowledged weight loss success.

Since Ozempic went viral, some doctors have been inundated with inquiries.

Dr. Nancy Raanama, an internist and obesity medicine expert in Beverly Hills, California, said:

This poses a problem for diabetics who struggle to get the prescriptions they need.

Ozempic’s maker Novo Nordisk said rising demand for the drug and supply chain problems are affecting supply. The U.S. Food and Drug Administration lists the drug as “currently in short supply.” on that website.

Ozempic is the brand name for semaglutide, a drug for adults with type 2 diabetes that patients self-inject subcutaneously. This is a class of drugs called GLP-1 receptor agonists, which work by mimicking the natural hormones your body releases when you eat food.

“It regulates your blood sugar, but it also targets areas of the brain that signal satiety or fullness, so it can definitely help with weight loss,” says NBC News medical contributor Dr. Natalie Azar. Told.

Ozempic’s sister drug, Wegswhich have Approved by the FDA for weight loss in obese patients, it also contains semaglutide, but the injector pen is slightly different and has a different dose. It’s also listed as “currently in short supply” by the FDA.

Novo Nordisk, which also manufactures Wegovy, has asked doctors not to administer the drug to new patients following “unprecedented product demand and short-term manufacturing challenges.” listed on its websiteThe company plans to make Wegovy available in all dosage strengths in the United States towards the end of the year.

The average weight loss with Ozempic is 14 pounds, but more with Wegovy, about 15 percent of the patient’s body weight, Azar said. “For anyone who needs this medically-controlled weight loss, it’s a great tool in their toolbox. But the shortage is real — it’s partially supplied, but how much is this impacting?” I see?” she wondered.

Wegovy and Ozempic contain the same active ingredient, but Novo Nordisk says they are not compatible. “We do not promote, suggest or encourage the off-label use of our medicines,” the company said in a statement.

But the FDA told NBC News that medical professionals can choose to prescribe off-label drugs when they are “medically appropriate.”

Is it safe?

YouTube user Ana McKenna, who documented her 45-pound weight loss journey on Ozempic, told TODAY that it was “the easiest weight loss attempt and the most successful.” Noted the side effects and agreed it was not a magic pill.

Other side effects of Ozempic include nausea, vomiting, pancreatitis and kidney failure, warns Azar. “It could potentially hurt you,” she said.

Ozempic costs about $900 per month, according to the drug company’s website. Off label use is usually not covered by insurance.

Drugs have to be taken indefinitely — people have to keep taking them for it to keep working. Drugs can’t necessarily reset a person for life, she added.

A big question is how people who aren’t diabetic or obese get the drug. did.

“[Physicians]prescribe off-label drugs, but the decision needs to be shared and the patient needs to understand the potential risks that may arise. It’s at the provider’s discretion.” ‘ she said.

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