Health
New treatment for sleeping sickness could eliminate ‘nightmare sickness’
Acodibolol was administered to 208 patients at 10 hospitals in the Democratic Republic of the Congo and Guinea during the 18-month trial. There were no safety red flags, and Sanofi planned to submit the data to the European Medicines Agency in hopes of broader deployment.
Regulatory authorities were involved in the design of the trial and approved the decision not to have a control arm due to patient enrollment difficulties.
This is partly because tolls have fallen sharply over the past two decades. In 1998, at least 40,000 cases were reported each year, but in 2020, that number has dropped to less than 1,000. However, the disease has a history of relapses, necessitating the development of effective therapies.
Experts now hope that acodibolol will allow other countries to follow in the footsteps of countries like Benin, Uganda and Rwanda that cleared out at least one form of sleeping sickness earlier this year.
Dr. Antoine Tarral, director of DNDi’s Sleeping Sickness Program and co-author of the paper, said:
Learn more to protect yourself and your family global health security
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